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Integrative Application of Human and Pathogen Genomic Information for Tuberculosis Control

Infectious Diseases Control

Kingdom of Thailand

Finished

Integrative Application of Human and Pathogen Genomic Information for Tuberculosis Control

Helping Tuberculosis Patients: Strengthening TB Control Strategies through Genomic Analysis!

Principal Investigator

- Prof.
  TOKUNAGA Katsushi
  Graduate School of Medicine, The University of Tokyo
- Dr.
  Surakameth Mahasirimongkol
  Senior Physician, Department of Medical Sciences, Ministry of Public Health

ODA Recipient Country

Kingdom of Thailand

Research Institutions in Japan

The University of Tokyo / RIKEN / Research Institute of Tuberculosis (JATA) / Fukujuji Hospital (JATA)

Research Institutions in Counterpart Country

Ministry of Public Health, Thailand / Mahidol University

Adoption fiscal year

FY 2014

Research Period

4 Years

Overview of the Research Project

Revealing genetic risks of tuberculosis and developing effective treatments for tuberculosis
　Tuberculosis is an infectious disease and its burden for global health is well-known as HIV and malaria. Thailand is one of 22 high burden countries of tuberculosis, and effective measures are required to control this disease urgently. Genome variation in both humans and TB bacteria may affect different phenotype and treatment. This large-scale study will analyze the variation of both host and pathogen genomes among TB patients, patients who suffered side effects from the medication, and individuals who have not developed TB, in order to reveal how genomic DNA variants are associated with the development of TB and the side effects of the drug treatment.

Tuberculosis control will be advanced in Thailand and world through the application of genomic information
　From the results of the genomic analysis, this project will identify genetic factors associated with tuberculosis and establish highly effective and less side-effect causative treatment method. The research finding will contribute to reduce TB patients and provide better quality of life to the patients globally.