Nobuyasu Shiga * Shunsuke Adachi Shoji Ishizaka Hiroshi Uji-i Hisaki Oka
Shinzi Ogasawara Tetsuo Okutsu Yasuyuki Ozeki Shin-ichi Zaitsu Smith Nicholas, I
Kenji Tamasaku Koji Hatanaka Yuriko Higuchi Shinji Masuda Tomoyuki Yatsuhashi

* 5Years

Development of photoresponsive nucleic acids and their application to photoregulation of gene expression in a single living cell

Shinzi Ogasawara

Hokkaido University
Creative Research Institution
Assistant Professor

URL :

Research Theme

The life is managed by precisely controlling the gene expression. Especially, localization of mRNA is great conditioning the cell fate in the early development phase. In the present study, I will develop the new method to regulate the translation of mRNA in a single living cell by “Light”, which allow accurate and easy control of the location, dosage, and time when an event occurs. This method will be an innovative technology for all bioscience research such as a differentiation control of the iPS cell.