Home » Researcher » phase1(2008) » Takeharu Nagai
|Takeharu Nagai *|
|Kohei Imura||Izumi Iwakura||Kaoru Ohta||Gen Sazaki||Yuki Sudo|
|Shinsuke Takagi||Hiromichi Niikura||Satoshi Nishimura||Tsuyoshi Fukaminato||Yuichi Fujita|
Invention of high performance bright luminescent proteins used as a nanolight source
The Institute of Scientific and Industrial Resarch
URL : http://www.sanken.osaka-u.ac.jp/jp/organization/thi/thi_07.html
By means of genetical evolution in vitro, much brighter luciferase and their wavelength mutants will be developed. These luminescent proteins will be used as light souces illuminating restricted region at nano meter scale to enable both single molecule imaging inside living cells and functional imaging in whole body. Furthermore, cells which produces a luminescent substrate for luciferase will be also developed to achieve completely automated luminescence system toward an ultimate bioimaging..