Research and Development of Therapeutic Products against Infectious Diseases, especially Dengue Virus Infection
Prof.
IKUTA Kazuyoshi
Kingdom of Thailand
Osaka University
National Institute of Health (NIH), Ministry of Public Health / Mahidol University (MU)
FY 2008
4 Years
Finding candidate therapeutic agents for infectious diseases prevalent in Southeast Asia
Dengue fever is a viral disease spread by mosquitoes that infects 50 million people living in the tropics every year, with about 200,000 fatalities, but no effective therapies have yet been established. However, whenever someone is infected by a disease agent, his or her body makes proteins called antibodies. The key role of those antibodies is to control the symptoms of the disease and cure the patient. We are conducting research that involves taking antibodies from dengue fever patients that seem to be useful against the disease, and attempting to use them as medicine. At the same time, we are conducting similar research for influenza, which is a worldwide problem, and for the botulinum toxin, which is a problem in Thailand. We are also searching microorganisms prevalent in Thailand for compounds that are effective as a dengue fever treatment.
Conducting experiments to develop new drugs following the successful creation of antibodies
We have succeeded in creating many antibodies against the dengue virus, influenza virus and botulinum toxin. Many of those antibodies appear to be potentially effective as therapeutic agents. Next, we will perform more detailed evaluations, aiming for the development of new drugs.
Japan Science and Technology Agency (JST)
Department of International Affairs
SATREPS Group
TEL : +81-3-5214-8085
Infectious Diseases Control
Integrative Application of Human and Pathogen Genomic Information for Tuberculosis Control
Environment / Energy
(Global-scale environmental issues)
Utilization Technology of Rubber Seeds for Green Products to Mitigate Global Warming and Plastic Pollution
Environment / Energy
(Global-scale environmental issues)
Establishing Sustainable Water Supply System Resilient to the Contamination of Drinking Water Sources
Environment / Energy
(Global-scale environmental issues)
Establishment of Risk Management Platform for Air Pollution in Cambodia