- JST Home
- /
- Strategic Basic Research Programs
- /
ERATO
- /
- Research Area/Projects/
- Completed/
- NOYORI Molecular Catalysis
Research Director: Dr. Ryoji Noyori
(Professor, School of Science, Nagoya University)
Research Term: 1991~1996
Guided by the theme "from ready-made to tailor-made catalysts", this project focused on efficient reactions which can make both right- and left-handed molecules, either large or small, natural or synthetic, with high enantiomeric purity. It also examined catalysts for the synthesis of stereo-regular polymers in which all of the chains are the same length. Strong emphasis was placed on the efficient synthesis of bio-active compounds, since many active sites interact with molecules through molecular recognition, where matching of chirality plays a key role. In all of this research activity the basic strategy involved synthesizing well-shaped organic compounds, then attaching them to a central metal; it was thus possible to control the reactivity of the central metal through such a coordination of the organic ligand. High purity at the molecular level provides significant power to create new functions and materials.
Supercritical carbon dioxide can be hydrogenated rapidly with Ru(II) complex catalysts to afford formic acid, methyl formate, and dimethylformamide in high yield.
Supercritical carbon dioxide or flons are usable as reaction media for highly selective asymmetric hydrogenation of certain olefins catalyzed by chiral transition metal complexes.
A Ru-phosphine-1,2-diamine combined catalyst effects hydrogenation of C=O function preferentially over coexisting C=C or CzC linkage. This new hydrogenation is very rapid and highly productive, and is superior to any existing metal hydride reactions. This method exhibits promise for the practical synthesis of a wide range of important alcoholic compounds.
Proper selection of the phosphine and diamine ligands in the Ru-phosphine-1,2-diamine catalyst allows highly efficient hydrogenation of chiral and achiral ketones with unprecedented diastereo- or enantioselectivity. The technical applicability is enormous.
Newly designed Ru(II) complexes having arene and chiral 1,2-diamine auxiliaries effect the highly enantioselective reduction of ketones or imines using 2-propanol or formic acid as a hydrogen donor. A wide array of alcohols and amines of high optical purity are accessible.
Organo-rhodium(I) complexes possessing phosphoine and diene ligands initiate polymerization of phenylacetylenes in a living and stereospecific manner. This method allows the synthesis of the homo- and block-polymer with a narrow dispersity.
Organo-rhodium Catalyst
Poly (phenylacetylene) having a helical structure