[Cell Dynamics]Spatiotemporal dynamics of intracellular components

Strategic Objective

Functional dynamics in the cell

Research supervisor


Endo Toshiya (Professor, Faculty of Life Sciences, Kyoto Sangyo University)


 This research area aims to gain an integrated understanding of the structure-function relationship of the cell by observing and measuring the dynamics in microspace of cellular higher-order structural components, from supramolecular complexes to organelles and membrane-less organelles, and analyzing their functional correlations.
 In recent years, the development of observation and measurement techniques such as cryo-electron microscopy, super-resolution microscopy, and high-speed atomic force microscopy have greatly improved our understanding of intracellular microstructure and dynamics. This has led to a rapid increase in structural information on large membrane-protein complexes and new phenomena, such as biological phase separation and inter-organelle contacts, which have led to a rethinking of the conventional concept of the cell. On the other hand, for an integrated understanding of the cell, it is necessary to promote bidirectional approaches by increasing the sizes of the targets for high-resolution structural analyses and in turn, increase the resolution of cellular imaging analyses and to obtain precise knowledge of the intracellular higher-order structural components and integrate them.
 In this research area, we aim to develop technologies for observation, measurement, and control of intracellular phenomena to overcome the above-mentioned issues, and to elucidate the functions of higher-order intracellular structural components based on these technologies, in order to understand new biological phenomena.

Research Area Advisors

Atsushi Inoue Head of Planning and Operation Group, Planning and Operation, hhc Data Creation Center,Eisai Co., Ltd.
Kenji Inaba Professor, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Takashi Ueda Professor, Division of Cellular Dynamics, Institute for Basic Biology
Yuko Okamoto Professor, Graduate School of Science, Nagoya University
Motomu Kanai Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Masahide Kikkawa Professor, Graduate School of Medicine, The University of Tokyo
Noriko Gotoh Professor, Cancer Research Institute, Kanazawa University
Ichio Shimada Team Leader, Center for Biosystems Dynamics Research, RIKEN
Yoko Toyoshima Emeritus Professor, Graduate School of Arts and Sciences, The University of Tokyo
Katsumasa Fujita Professor, Department of Applied Physics, Osaka University
Atsuko Yamashita Professor, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yoshihiro Yoneda Director, The Research Foundation for Microbial Diseases of Osaka University

Research Projects

  1. Year Started : 2020
  2. Year Started : 2021

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