[Extracellular Fine Particles] Year Started : 2018

Ken Ishii

Immune response to, and regulation by, extracellular nucleic acids

Research Director
Ken Ishii

Professor
Institute of Medical Science
The University of Tokyo

Collaborator
Taro Kawai Professor
Science and Technology Division of Biological Science Discipline of Biomedical Science
NARA Institute of Science and Technology
Yoshitaka Shirasaki Project Research Associate
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Cevayir Coban Professor
The Institutel of Medical Science
The University of Tokyo
Outline

Nucleic acids, normally reside within cells and work as a blueprint of life; however, recent evidence suggest that nucleic acids can be found outside of cells acting as genetically, epigenetically and immunologically active nanoparticle. We will develop analytical tools and elucidate physiological role of extracellular nuclic acids.

Kenichi Suzuki

Unraveling ofmembrane mechanisms of exosomes by high-resolution single-molecule imaging

Research Director
Kenichi Suzuki

Professor
Institute for Glyco-core Research
Gifu University

Collaborator
Hiromune Ando Professor
Institute for Glyco-core Research
Gifu University
Kizuka Yasuhiko Associate Professor
Institute for Glyco-core Research
Gifu University
Yan Xu Associate Professor
Graduate School of Engineering
Osaka Metropolitan University
Shinya HANASHIMA Associate Professor
Graduate School of Science
Osaka University
Outline

In this study, we aim to unravel the mechanisms of how exosomes from metastatic cancer cells are bound to the target cell membranes, how the exosomes are internalized by the cells, and how molecules from the exosomes work in the target cell membranes by taking advantage of lipid rafts and glycans. Based on the results, we try to make function of the exosomes controllable. For this purpose, we will use and improve high-resolution single-molecule imaging and super-resolution imaging as core technologies.

Masato Hasegawa

Molecular mechanisms of the formation and propagation of fibrillar protein particles that cause neurodegeneration.

Research Director
Masato Hasegawa

Project Leader
Department of Brain & Neurosciences
Tokyo Metropolitan Institute of Medical Scienc

Collaborator
Kaoru Yamada Assistant Professor
Graduate School of Medicine
The University of Tokyo
Yukiko Yoshida Chief Researcher
Department of Basic Medical Sciences
Tokyo Metropolitan Institute of Medical Science
Outline

Abnormal protein particles formed in cells are involved in the pathogenesis and progression of dementia and neurological diseases. In this research, we will comprehensively analyze the molecules associated with the process of formation, release, and propagation of the intracellular protein particles and elucidate the molecular mechanisms. We will also try to develop new detection systems for intracellular and extracellular pathogenic protein particles to identify the biomarkers of these diseases and novel strategies for treatments by inhibiting cell to cell propagation of the pathological proteins.

Rikinari Hanayama

Elucidation and Control of crosstalks among biological responses caused by extracellular fine particles

Research Director
Rikinari Hanayama

Professor
Nano Life Science Institute
Kanazawa University

Collaborator
Hiroki Ida Specially Appointed Associate Professor
Graduate School of Engineering
Nagoya University
Takafumi Seto Professor
College of Science and Engineering
Kanazawa University
Takahiro Hamada Associate Professor
Faculty of Life Science
Okayama University of Science
Hideki Mochiduki Professor
Graduate School of Medicine
Osaka University
Outline

The leading players that mediate biological responses against extracellular fine particles are phagocytes which engulf them first in our body. The phagocytes trigger defensive inflammatory responses to maintain homeostasis at first, but when this process becomes excessive, they turn to promote offensive inflammatory responses that destroy their surrounding environment. In this research project, by developing methods to analyze real physiological functions and in vivo dynamics of extracellular fine particles, we will analyze inflammatory responses against exosomes and aerosols to elucidate and control the mechanisms how their crosstalks turn the inflammatory responses to be offensive.

Shiro Fukita

Intracellular fate of extracellular fine particles and the control system

Research Director
Shiro Fukita

Professor
Institute for Chemical Research
Kyoto University

Collaborator
Akiko Eguchi Associate Professor
Graduate School of Medicine
Mie University
Ikuhiko Nakase Professor
Graduate School of Science
Osaka Metropolitan University
Takuro Nidome Professor
Faculty of Advanced Sceince and Technology
Kumamoto University
Takashi Morii Professor
Institute of Advanced Energy
Kyoto University
Outline

Macropinocytosis is a central pathway to the cellular uptake of extracellular fine particles. In this research project, we aim to elucidate the methods of cellular uptake and the intracellular fate of extracellular fine particles, having various physicochemical properties, via developing novel sensing systems of the intracellular environment. We also aim to understand the effects of extracellular fine particles on biological phenomena in terms of chemical, biological and pharmaceutical point of views, contributing to development of drug discovery and therapeutic technologies for healthy and sustainable life.

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