Research Director: Makoto Arita
(Professor, Keio University Faculty of Pharmacy / Team leader, Center for Integrative Medical Science, RIKEN)
Research Term: Oct 2021 - Mar 2027
Grant Number: JPMJER2101

In this project, we will create a “lipidome atlas” that captures lipid diversity, distribution, localization, and lipid modification in life as a whole. Based on the non-targeted lipidomics, we will build a basic technology that combines spatial lipidomics to investigate the localization of lipids, innovative proteomics to understand lipid metabolic enzymes and modifications, and spatial transcriptomics to elucidate the factors of lipid localization. In this way, we will visualize the effects of the local environment created by specific lipids on the dynamics and functions of multicellular systems. In addition, we will elucidate the mechanisms that regulate lipid diversity and its localization in vivo, to understand the biological significance of lipid diversity, and to elucidate diseases caused by its disruption.

Research Groups

- Lipid diversity and spatial lipidomics group
- Lipid-related functional genomics group
- Lipid-related proteomics group
- Lipid-related bioinformatics group
- Lipid biology group

Project Headquarters

Keio University Faculty of Pharmacy
Bldg.3 703, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512