Research Director: Hiroki R. Ueda
(Professor, Graduate School of Medicine, The University of Tokyo / Team leader, Center for Biosystems Dynamics Research, RIKEN)
Research Term: Oct 2020 - Mar 2026
Grant Number: JPMJER2001

Based on the determination of the genome sequence, systems biology, which is the study of the function of biological systems based on the interactions among its components, has been developed. However, since mammals, especially humans have extremely complex biological systems including social and environmental factors in real-world settings, human systems biology not yet been fully established.

This project aims to elucidate the biological timing mechanisms underlying sleep-wake cycles by applying state-of-the-art technology in mouse genetics and human sleep measurement techniques. Centered on the phosphorylation hypothesis of sleep proposed by Ueda, this project explores relevant genes from human population data, identify genotype-phenotype causality relationships, and control gene product activities.

Research Groups

- Human sleep measurement group
- Animal analysis group
- Molecular regulation group

Project Headquarters

Hongo 7-3-1, Bunkyo-Ku, Tokyo, Japan
Exp. Res. Bldg. 8F south S801