Research Director: Hitoshi KURUMIZAKA
(Professor, Institute for Quantitative Biosciences, The University of Tokyo)
Research Term: Oct 2019 - Mar 2025
Grant Number: JPMJER1901

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure plays a crucial role in the regulation of genomic DNA functions, its disruption leading to various diseases. Therefore, understanding the chromatin structure-based mechanisms that regulate the use of the genetic information is crucial for designing new therapeutic strategies.

Based on advanced cryo-electron microscopy technology we will try to determine the structures and functions of various chromatin units. Our project goal is to elucidate “chromatin atlas” representing the ensemble of these structures. Through these studies, we aim to create a new concept in regulatory mechanisms of genetic information.

Research Groups

- Chromatin structure research group
- Organic Synthesis chemistry research and development group
- Phenotype analysis research group

Project Headquarters

Institute for Quantitative Biosciences Life Science Research Bldg. B 303
Yayoi 1-1-1 Bunkyo-ku
Tokyo 113-0032