Reserach

Researchers

CRESTPRESTO
  • FY 2010
  • FY 2011
  • FY 2012

  • Team OSHIMA
  • Team KUMANOGOH
  • Team SAKAGUCHI
  • Team TAKEUCHI

Shimon SAKAGUCHI - Devising novel methods to control chronic inflammation via regulatory T cells.

Principle Investigator

Shimon SAKAGUCHI
Osaka University
Professor
Research Theme
Devising novel methods to control chronic inflammation via regulatory T cells.

Regulatory T cells are a lymphocyte population that is specialized for suppressing abnormal or excessive immune responses. They can be exploited to suppress chronic inflammation in autoimmune disease and chronic rejection in organ transplantation or to enhance immune responses in tumor immunity and chronic infection. We plan to devise novel methods to control immune responses via targeting regulatory T cells either by attenuating or strengthening their suppressive activity.

Research Results
The 5 Cardinal Signs of Inflammation