Chronic inflammation and diseases
Chronic inflammatory disease
Various kinds of diseases are accompanied by chronic inflammation. Allergic diseases (e.g., asthma, atopic dermatitis) and autoimmune diseases (e.g., rheumatoid arthritis) are well-known examples. However, these diseases are not linked to immediate death, and instead lead to long-term persistence of severe symptoms. A possible consequence of the structural changes relates to functional impairment of the inflamed tissues during the long disease process, which is also a considerable problem.
Chronic inflammation pertains to lifestyle-related diseases and senescence
Although relationships between chronic inflammation and lifestyle-related diseases have historically been neglected, recent studies have revealed the involvement of chronic inflammation in these diseases. Evidence has emerged, suggesting relationships among chronic inflammation, age-related diseases (cancer, arteriosclerosis, obesity, Alzheimer's disease), and senescence itself. These studies suggest that inapparent changes in the chronic inflammatory responses in the early stages of disease are critical factors for disease promotion. Therefore, the mechanism of "natural inflammation" is thought to play an important role in the development and maintenance of chronic inflammation status.
