Research Theme

Pathophysiological role of chronic inflammation in aging-associated diseases

Chronic inflammation is linked to aging-associated diseases such as heart failure, diabetes, and atherosclerosis. However, the pathophysiological role of chronic inflammation in aging-associated diseases is currently unknown. We have recently found that the C1q component of the complement system is increased in multiple tissues of aged animals and contributes to the onset of heart failure, diabetes, and atherosclerosis. The ultimate goal of this study is to identify the mechanisms by which C1q promotes the onset of aging-associated diseases and to develop novel therapeutic strategies for the diseases linked to chronic inflammation.

Research Results