R&D Project

OHNO Shigeo PM Photo

Goal 2 R&D Projects (Selected in 2020)Challenge toward the Control of Intractable Cancer through Understanding of Molecular, Cellular, and Interorgan Networks

Project manager (PM)OHNO ShigeoSpecial Contract Professor, Graduate School of Medicine, Juntendo University

Summary of the project

In Japan, more than half of the population suffers from cancer, and one in several people dies of cancer. Even if an excellent drug is developed, the situation continues that we cannot know whether it is effective for ourselves until we use it. Among them, refractory cancer poses the most serious threat, largely due to the fact that the cause of refractory cancer is largely unknown and early diagnosis methods have not been established.
To date, basic cancer research has been conducted using animal models and established cancer cell lines due to various technical and social constraints. However, with the advent of various innovative technologies such as genome analysis technology from minute samples and patient organoid technology, new cancer research is expanding utilizing patient biometric data obtained from cancer patient clinical samples.
In this project, we will promote efforts to further deepen and solidify these technologies. Specifically, it is the development of technologies and research bases for collecting and accumulating clinical specimens and data including early stage cancers, technologies and research bases for identifying key factors for prediction and prevention and technology and research infrastructure to identify the role of the given factors in the pathogenesis process.
By conducting these efforts in an integrated manner, we will develop and maintain several basic technology groups necessary for the prediction and prevention of intractable cancers. At the same time, we will promote the development of new diagnostic markers and therapeutic targets that enable the prediction and prevention of intractable cancers.
We develop innovative technologies for prevention, diagnosis, and treatment to turn intractable cancers into curable cancers by year 2030. We aim to create a society in which everyone can get precision medicine of cancer at any moment by year 2050.

Milestone by year 2030

We develop innovative technologies for prevention, diagnosis, and treatment to turn intractable cancers into curable cancers.

Milestone by year 2025

We develop biomarkers and therapeutic target molecules for early detection of intractable cancers.

R&D theme progress reports

Performers

Theme [1] SENO Hiroshi Kyoto University
Theme [1] KODAMA Yuzo Kobe University
Theme [1] KAKIUCHI Nobuyuki Kyoto University
Theme [1] IMAI Toshio Kobe University
Theme [1] SATO Toshiro Keio University
Theme [1] KATAOKA Keisuke Keio University
Theme [1] SHINOHARA Masakazu Kobe University
Theme [1] KABE Yasuaki Kochi Medical School
Theme [1] KATAGIRI Toyomasa National Institutes of Biomedical Innovation, Health and Nutrition
Theme [1][3] OHNO Shigeo Juntendo University
Theme [2] KUBOTA Hiroyuki Kyushu University
Theme [2] YAMAMOTO Yoichiro RIKEN
Theme [2] TAKEBE Takanori The University of Osaka
Theme [2] HIRATSUKA Toru Osaka International Cancer Institute
Theme [2] URANO Yasuteru The University of Tokyo
Theme [2] YONEMURA Shigenobu Tokushima University
Theme [2] KURODA Masafumi The University of Tokyo
Theme [3] HARA Eiji The University of Osaka
Theme [3] HATTORI Ayuna Kyoto University
Theme [3] YAMASHITA Akio Kindai University
Theme [3] ICHIJO Hidenori Institute of Science Tokyo
Theme [3] NAGANO Osamu Fujita Health University
Theme [3] TAKAHASHI Akiko Japanese Foundation for Cancer Research
Theme [3] MINAMI Yasuhiro Kobe University
Theme [3] FUJITA Yasuyuki Kyoto University
Theme [3] OHSAWA Shizue Nagoya University

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