R&D Project

Goal 2 R&D Projects (Selected in 2020)Challenge toward the Control of Intractable Cancer through Understanding of Molecular, Cellular, and Interorgan Networks
Project manager (PM)OHNO ShigeoSpecial Contract Professor, Graduate School of Medicine, Juntendo University
Summary of the project
In Japan, more than half of the population suffers from cancer, and one in several people dies of cancer. Even if an excellent drug is developed, the situation continues that we cannot know whether it is effective for ourselves until we use it. Among them, refractory cancer poses the most serious threat, largely due to the fact that the cause of refractory cancer is largely unknown and early diagnosis methods have not been established.
To date, basic cancer research has been conducted using animal models and established cancer cell lines due to various technical and social constraints. However, with the advent of various innovative technologies such as genome analysis technology from minute samples and patient organoid technology, new cancer research is expanding utilizing patient biometric data obtained from cancer patient clinical samples.
In this project, we will promote efforts to further deepen and solidify these technologies. Specifically, it is the development of technologies and research bases for collecting and accumulating clinical specimens and data including early stage cancers, technologies and research bases for identifying key factors for prediction and prevention and technology and research infrastructure to identify the role of the given factors in the pathogenesis process.
By conducting these efforts in an integrated manner, we will develop and maintain several basic technology groups necessary for the prediction and prevention of intractable cancers. At the same time, we will promote the development of new diagnostic markers and therapeutic targets that enable the prediction and prevention of intractable cancers.
We develop innovative technologies for prevention, diagnosis, and treatment to turn intractable cancers into curable cancers by year 2030. We aim to create a society in which everyone can get precision medicine of cancer at any moment by year 2050.
Milestone by year 2030
We develop innovative technologies for prevention, diagnosis, and treatment to turn intractable cancers into curable cancers.
Milestone by year 2025
We develop biomarkers and therapeutic target molecules for early detection of intractable cancers.
R&D theme progress reports
- [1] Development of technologies for collecting patient biospecimens and data for the realization of optimal medicine (My Medicine)
- [2] Technology development for integrated analysis and verification of patient biometric data
- [3] Technology development for the creation of innovative diagnostic and treatment concepts based on understanding of the onset process of cancer
- Progress Report (1.95MB)
Performers
Theme [1] | SENO Hiroshi | Kyoto University |
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Theme [1] | KODAMA Yuzo | Kobe University |
Theme [1] | KAKIUCHI Nobuyuki | Kyoto University |
Theme [1] | IMAI Toshio | Kobe University |
Theme [1] | SATO Toshiro | Keio University |
Theme [1] | KATAOKA Keisuke | Keio University |
Theme [1] | SHINOHARA Masakazu | Kobe University |
Theme [1] | KABE Yasuaki | Kochi Medical School |
Theme [1] | KATAGIRI Toyomasa | National Institutes of Biomedical Innovation, Health and Nutrition |
Theme [1][3] | OHNO Shigeo | Juntendo University |
Theme [2] | KUBOTA Hiroyuki | Kyushu University |
Theme [2] | YAMAMOTO Yoichiro | RIKEN |
Theme [2] | TAKEBE Takanori | The University of Osaka |
Theme [2] | HIRATSUKA Toru | Osaka International Cancer Institute |
Theme [2] | URANO Yasuteru | The University of Tokyo |
Theme [2] | YONEMURA Shigenobu | Tokushima University |
Theme [2] | KURODA Masafumi | The University of Tokyo |
Theme [3] | HARA Eiji | The University of Osaka |
Theme [3] | HATTORI Ayuna | Kyoto University |
Theme [3] | YAMASHITA Akio | Kindai University |
Theme [3] | ICHIJO Hidenori | Institute of Science Tokyo |
Theme [3] | NAGANO Osamu | Fujita Health University |
Theme [3] | TAKAHASHI Akiko | Japanese Foundation for Cancer Research |
Theme [3] | MINAMI Yasuhiro | Kobe University |
Theme [3] | FUJITA Yasuyuki | Kyoto University |
Theme [3] | OHSAWA Shizue | Nagoya University |
PDF Download
- Summary of the project (266KB)