※ Affiliations and titles are as of the end of the research activity.
Research Supervisor
Soichi Wakatsuki(Professor of Photon Science, SLAC National Accelerator Laboratory, USA / Professor of Structural Biology, School of Medicine, Stanford University)
Overview
This Research Area aims to integrate cutting-edge life science research with advanced core technologies in structural biology to create a new research field, “structural life science” which will lead to innovation in life science. It will address fundamental problems in life science by seamlessly integrating advanced methods of structural analysis and establishing general principles for elucidating and predicting the dynamics of hierarchical structures ranging from the atomic level to the cellular or tissue level.
This PRESTO covers the following research areas with a particular emphasis on proteins because of their essential roles in molecular recognitions in wide ranging biological phenomena:
1) Elucidation of molecular mechanisms of biological functions or control thereof through hierarchical understanding of protein-protein interactions, interactions of proteins with other biological macromolecules such as nucleic acids or lipids, or spatiotemporal changes of higher-order structures caused by endogenous/exogenous small molecules or post-translational modifications of proteins including glycosylation, ubiquitination, phosphorylation, and methylation.
2) Molecular control or design of macromolecular complexes using chemical biology or other novel methodologies.
3) Development of novel technologies for structural and functional analyses with variety of spatiotemporal resolutions and physiological conditions (from in vitro to in vivo). Applications included in this endeavor are crystal structure analyses, solution scattering, nuclear magnetic resonance, electron microscopy, cell imaging, mass spectroscopy, computational science, bioinformatics, and various biophysical analyses of molecular interactions.
4) Novel correlative structural analysis methods, or integrated structural biology, that correlates a number of complementary techniques in a synergistic manner to study hierarchical dynamics of biological molecules and their complexes, organelles, cells and tissues, involved in important biological functions.
To achieve these objectives, we encourage original research proposals on challenging problems in life science by using cutting-edge structural biology approaches as well as those which aim to develop novel structural biology methodologies to address important questions in molecular cell biology, medicine, or pharmacology.
Research Area Advisors
Midori Kamimura |
Fuyuhiko Inagaki |
Sou Iwata |
Toshihiko Ogura |
Taro Kinoshita |
Genji Kurisu |
Hitoshi Sakashita |
Shigetoshi Sugio |
Junichi Takagi |
Kazuhiro Nagata |
Haruki Nakamura |
Osamu Nureki |
Yoshie Harada |
Atsushi Miyawaki |
Minoru Yoshida |
Year Started: 2012
Researcher
Minoru Kubo
Researcher
Takahide Kon
Researcher
Tsukazaki Tomoya
Researcher
Akihiro Narita
Researcher
Motoyuki Hattori
Researcher
Takashi Fujii
Researcher
Yuichiro Hori
Researcher
Tomoko Masaike
Researcher
Kouta Mayanagi
Researcher
Takeshi Murata
Researcher
Kazuhiro Yamada
Year Started: 2013
Researcher
Naruhiko Adachi
Researcher
Kohsuke Inomata
Researcher
Takumi Ueda
Researcher
Noriyuki Kodera
Researcher
Tadashi Sato
Researcher
Ayumi Sumino
Researcher
Kotaro Nakanishi
Researcher
Hiroshi Nishimasu
Researcher
Takeshi Noda
Researcher
Maho Hamasaki
Researcher
Ayori Mitsutake
Researcher
Rikiya Watanabe
Year Started: 2014
Researcher
Kyohei Arita
Researcher
Tsuyoshi Imasaki
Researcher
Tomohide Saio
Researcher
Narinobu Juge
Researcher
Koh Takeuchi
Researcher
Kohei Takeshita
Researcher
Hiroshi Nakagawa
Researcher
Tomohiro Nishizawa
Researcher
Kunio Hirata
Researcher
Tsuyoshi Hirota