Understanding Life by iPS cells Technology

※ Affiliations and titles are as of the end of the research activity.

Strategic Objective

Creating fundamental technologies for advanced medicine through generation and regulation of stem cells, based on cellular reprogramming

Research Supervisor

Shin-ichi Nishikawa(Deputy Director, Center for Developmental Biology, RIKEN)

Overview

 This research area comprises several fields (including cellular reprogramming, transdifferentiation and stem cell biology) in which major breakthroughs are expected by use of the technology involved in establishing induced pluripotent stem (iPS) cells. Basic research on pioneering new approaches or having the potential for clinical medicine will be also involved. Specifically included are 1) advancing and simplifying reprogramming technologies based on the molecular mechanisms of cellular reprogramming, 2) analysis and directed induction of stem cell differentiation and transdifferentiation processes, 3) elucidation of the molecular mechanisms underlying epigenetic alteration during iPS formation, 4) elucidation of pathogenesis of various diseases through the effective use of iPS cells, and 5) development of animal models for human diseases using iPS cells. We believe that the results of this research will contribute to the identification of the causes of diseases as well as to the development of new therapeutic drugs and pave the way to realize cell transplant treatments without ethical problems and immunologic rejection.

Research Area Advisors

Fumitoshi Ishino
Hideyuki Okano
Yumiko Saga
Hiromitsu Nakauchi
Hitoshi Niwa
Yutaka Hanazono
Hideyuki Haruyama

Year Started: 2008

Researcher
Araki Ryoko
Researcher
Kenji Osafune
Researcher
Satoshi Kishigami
Researcher
Erika Sasaki
Researcher
Atsushi Suzuki
Researcher
Ken-Ichiro Seino
Researcher
Kazuhito Tomizawa
Researcher
Shinji Masui
Researcher
Osam Mazda
Researcher
Yasuhiro Yamada

Year Started: 2009

Researcher
Masatsugu Ema
Researcher
Yasuhide Ohinata
Researcher
Hiroshi Kataoka
Researcher
Akira Kurisaki
Researcher
Akira Satoh
Researcher
Go Nagamatsu
Researcher
Noemi Fusaki
Researcher
Kyoji Horie
Researcher
Arata Honda
Researcher
Jiyoung Lee
Researcher
Tetsuro Watabe

Year Started: 2010

Researcher
Yasuji Kitabatake
Researcher
Keiko Shimojima
Researcher
Yasuhiro Takashima
Researcher
Jun K. Takeuchi
Researcher
Hidetoshi Date
Researcher
Akitsu Hotta
Researcher
Taro Muto
Researcher
Kazuhiro Yagita
Researcher
Tomonobu M Watanabe

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