[Supra-Biological Tissues] Creation of Supra-Biological Tissues through Understanding and Control of Multicellular Dynamics

Strategic Objective

Challenging to create suprabiological tissue

Research Supervisor

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Mototsugu Eiraku(Professor, Institute for Life and Medical Sciences, Kyoto University)

Overview

 This research area aims to understand the dynamics between cell-cell or cell-extracellular environment interactions at the field where cells form structures and perform functions, and to develop techniques to control cells using artificial materials, in order to construct complex tissues with properties, functions and mechanisms that can only be achieved by combining biological and artificial materials.
 Recent advances in metrology and biocompatible materials have enabled combining biological and functional materials. In this research area, by utilizing these technologies for integrating cell populations and artificial materials, and by measuring, predicting and controlling multicellular states, we challenge to understand fundamental phenomena in the field where cells structure and perform higher functions, such as cellular communication and cell-material interactions, by integrating biological and artificial materials. Moreover, by controlling and adjusting the existing functions of cell populations or imparting new functions, we attempt to create “supra living tissues” or to “go beyond conventional technologies” to get closer to biological tissues. Furthermore, research aimed at applications in fields such as agriculture and botany by using variety of materials including animal cells, is also included in the scope of this research area.
 We intend to integrate various scientific technologies, such as material, life sciences, engineering, materials science and mathematical science, and are taking on the challenge of creating ‘Supra-Biological Tissues’ through full-fledged interdisciplinary fusion by circulating knowledge between fundamental understanding of cells, materials and technology and the design and construction of tissues.

Research Area Advisors

Taiji Adachi Professor, Institute for Life and Medical Sciences, Kyoto University
Yasuhiro Inoue Professor, School of Engineering, Kyoto University
Hirohide Saito Professor, Institute for Quantitative Biosciences, The University of Tokyo / Professor, Center for iPS Cell Research and Application, Kyoto University
Masahiro Takinoue Professor, Department of Computer Science, Institute of Science Tokyo
Shoji Takeuchi Professor, Graduate School of Information Science and Technology, The University of Tokyo
Takanori Takebe Professor, Institute of Integrated Research, Institute of Science Tokyo / Professor, Graduate School of Medicine, The University of Osaka
Ayae Sugawara-Narutaki Professor, Institute of Integrated Research, Institute of Science Tokyo
Ryuichi Nishinakamura Professor, Institute of Molecular Embryology and Genetics, Kumamoto University
Honda Kohsuke Professor & Director, International Center for Biotechnology, The University of Osaka

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