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Exploration of host factors relating with RNA-polymerase stability
Influenza A viruses causing annual epidemics in human population are derived from the viruses of aquatic birds.
Gene sequences in eight segments of influenza A viruses are stablely maintained during proliferation in aquatic birds. But the viruses isolated from human patients show prone to have mutations in their gene sequences.
What is the determinant of differences in stability? I'd like to get an answer!