[Multicellular interaction] Development of technology platforms for quantitative analysis of spatiotemporal multicellular interaction

Strategic Objective

Development of core technology platforms for understanding spatiotemporal multicellular interaction

Research Supervisor


Michiyuki Matsuda (Professor, Graduate School of Biostudies, Kyoto University)


 This CREST project aims to develop novel analytical technologies and theories that lead to the understanding of the dynamics of biosystems through spatiotemporal analysis of multicellular interactions and the development of technologies at the molecular or cellular levels.

 With recent progress in omics and imaging technologies at the single cell level and in computer science, comprehensive and quantitative analysis of cells and biomolecules is becoming possible. This will lead to changes in life sciences methodologies in research that focuses on individual genes and molecules and in more complex analyses, such as targeting changes in many genes and molecules in single cells. However, there are many technological bottlenecks in the spatiotemporal analysis of cells and molecules, and in the three-dimensional analysis of tissues and organisms. Therefore, highly quantitative measurement methods and data analysis techniques that enable an understanding of spatiotemporal aspects of cellular and molecular dynamics in tissues and living organisms are required.

 This project, thus, aims to develop new technologies and theories that contribute to the understanding of the spatiotemporal aspects of cellular and molecular networks and to promote research and development on the elucidation of multicellular dynamics. In addition, we will build technology platforms to predict and manipulate multicellular dynamics based on high-quality data and parameters obtained through this research and development.

Research Area Advisors

Tsuyoshi Akagi Princepal Investigator, KAN Research Institite, Inc.
Takafumi Inoue Professor, School of Science and Engineering, Waseda University
Naoko Imamoto Chief Scientist, CPR, RIKEN
Hiroyuki Kobayashi Vice President, Digital intelligence Department, SHIONOGI & CO., LTD.
Yumiko Saga Professor, Department of Gene Function and Phenomics, National Institute of Genetics
Kazuhiro Sakurada Deputy Program Director, Medical Sciences Innovation Hub Program, RIKEN
Masaki Sano Deputy Director, Institute for Advanced Study, Tokyo College, The University of Tokyo
Yutaka Suzuki Professor, Graduate School of Frontier Sciences, The Universitu of Tokyo
Shin-ichi Tate Professor, Graduate School of Integrated Sciences for Life, Hiroshima University
Masami Hirai Team Leader, Center for Sustainable Resource Science, RIKEN
Tetsuya Matsuda Professor, Graduate School of Informatics, Kyoto University
Masahiro Yamamoto Professor, Research Institute for Microbial Diseases, Osaka University

Research Projects

  1. Year Started : 2019

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