Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins-

Research Supervisor

Tairo Oshima


Research in this field investigates the structure and the properties of proteins, which play a central role in biogenesis, as well as the possibilities for their application. More specifically, together with improving the analysis of protein structures, this field includes research on biological reactions such as catalytic activity, metabolic control and information transfer, which are based on dynamical changes in the protein structure. New measurement techniques and research methods are also sought for analyzing the mechanisms governing higher-order life phenomena, such as reproduction, immunity, the nervous system and environmental adaptation, as well as their application to drug discovery, diagnostic techniques and material production. In addition, another actively researched area includes the analysis of dynamical changes in structure and properties, such as denaturation and reconstitution, as well as the development of techniques for their control and improvement.

Year Started : 2003

Hiroyuki Araki
Professor, National Institute of Genetics
Structure and Function of the Protein Complexes in the Synthesis of Nucleic Acids
Noriyuki Sagata
Professor, Kyushu University
Analysis of the Structure and Function of Cell Cycle and Checkpoint Regulators
Masashi Suzuki
Group Leader, National Institute of Advanced Industrial Science and Technology (AIST)
DNA-recognition and Ligand-binding by the Feast/Famine Regulatory Proteins, FFRPs
Teizo Fujita
Professor, Fukushima Medical University
Analyzing Interaction among Protein Molecules in Host Defense and the Mechanism to Exert Function

Year Started : 2002

 Hidenori Ichijo
Professor, The University of Tokyo
Molecular Mechanisms of Recognition and Conversion of Stress Signaling
Koreaki Ito
Visiting Professor, Osaka University
Principles and Regulatory Devices that Govern the Dynamic Behaviors of Proteins in the Cell
Yuji Goto
Professor, Osaka University
The Molecular Pathogenesis of Amyloidosis
Hiroyuki Sorimachi
Project Leader, The Tokyo Metropolitan Institute of Medical Science
Elucidation of Physiological Functions of Intracellular Modulator Proteases
Akihito Yamaguchi
Professor, Osaka University
Studies on the Structure and Function of Xenobiotic Efflux Proteins
Tamotsu Yoshimori
Professor, Osaka University
Intracellular Traffic System Organized by Proteins and Membranes

Year Started : 2001

 Kazuhiro Iwai
Professor, Osaka City University
Analysis of the Ubiquitin-Mediated Regulation of Protein Functions
Masatsune Kainosho
Visiting Professor, Tokyo Metropolitan University
Developing a New Approach for High-throughput, High-accuracy NMR Structural Analyses of Genomic
Yuji C. Sasaki
Chief Scientist, Japan Synchrotron Radiation Research Institute
Analysis of Dynamical Function/Structure of Protein Molecules From Single- Molecular Experiment With X-rays
Yoshinori Shichida
Professor, Kyoto University
Structural and Functional Analyses of G Protein-Coupled Receptors Using Rhodopsin as a Model Receptor
Kazuhiro Nagata
Professor, Kyoto University
Quality Control Mechanism of Newly Synthesized Proteins in the Endoplasmic Reticulum
Toshio Hakoshima
Professor, Nara Institute of Science and Technology
Structural Basis of Protein Functions and their Regulation by Dynamic Complex Formation


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