[MultiSensing] Year Started : 2021

Takuya Sasaki

Brain integration of interoceptive information through the vagal afferents

Research Director
Takuya Sasaki

Professor
Graduate School of Pharmaceutical Sciences
Tohoku University

Collaborator
Yusaku Iwasaki Professor
Graduate School of Life and Environmental Sciences,
Kyoto Prefectural University
Hideki Ohira Professor
Graduate School of Informatics
Nagoya University
Outline

The brain integrates interceptive information. The vagal afferents play a crucial role in information transter from the periphral organs to the brain. This project aims to understand how the vagal afferents convert multiple periphral organ activity into interoceptive information and transfer and integrate such information into the brain, and how these body-brain signals contribute to diverse brain functions such as emotion and decision making in mice and humans.

Takao Someya

Electronic skin to unveil Yuragi mechanism of biological signals

Research Director
Takao Someya

Professor
Graduate School of Engineering
The University of Tokyo

Collaborator
Masayuki Amagai Professor
School of Medicine
Keio University
Outline

We aim to establish a technology for manufacturing an electronic skin system to simultaneously measure multiple biological signals throughout the body, enabling highly accurate and long term continuous measurement during daily activities. Signals obtained by continuous measurement from the surface of skin will be used as bio-alternative data and analyzed using AI algorithms to discover its medical significance. Early detection of transition from normal to pathological Yuragi will build a base for application to preventive medicine.

Akiyuki Taruno

Elucidation of the multi-sensing network underlying body fluid homeostasis

Research Director
Akiyuki Taruno

Professor
Graduate School of Medical Science
Kyoto Prefectural University of Medicine

Collaborator
Yasushi Okazaki Team Leader
Center for Integrative Medical Sciences
Riken
Hideaki Kato Associate Professor
Graduate School and College of Arts and Sciences
The University of Tokyo
Outline

The palatability of salt causes excess salt consumption in humans, which leads to hypertension and associated cardiovascular diseases. This project contributes to healthy longevity by creating a scientific basis of technological innovation for salt reduction. Critically salt and water preferences are contrastingly altered by changes in body fluid balance. Through data-driven research combining state-of-the-art technologies—large-scale multiomics, advanced multicolor optogenetics, and activity recordings—we will elucidate the neural basis that integrates taste and body hydration and ultimately controls salt and water consumption. The detailed understanding of salt perception will reveal novel targets for the reduction of dietary salt intake.

Yukie Nagai

Cognitive Feelings that Mediate Between Perception and Emotion

Research Director
Yukie Nagai

Project Professor
International Research Center for Neurointelligence
The University of Tokyo

Collaborator
Shinichiro Kumagaya Associate Professor
Research Center for Advanced Science and Technology
The University of Tokyo
Keisuke Suzuki Specially Appointed Lecturer
Center for Human Nature, Artificial Intelligence, and Neuroscience
Hokkaido University
Yuichi Yamashita Section Chief
National Institute of Neuroscience
National Center of Neurology and Psychiatry
Outline

This project aims to elucidate the principle of cognitive feelings based on predictive processing as a unified brain theory. Cognitive feelings include senses of knowing, confidence, reality, fluency, etc. about perceptual experiences. We hypothesize that perception and emotion about the perception are mediated by cognitive feelings. This project will provide a deeper and novel understanding of multi-sensing systems with cognitive feelings by integrating synthetic and analytic approaches.

Takashi Hanakawa

Investigation of human somatosensory network systems by means of hapticsmesh and cerebro-spinal neuroimaging

Research Director
Takashi Hanakawa

Professor
Graduate School of Medicine
Kyoto University

Collaborator
Mitsunari Abe Director
Integrative Brain Imaging Center
National Center of Neurology and Psychiatry
Takeshi Kobayashi Team Leader
Sensing System Research Center
National Institute of Advanced Industrial Science and Technology (AIST)
Hiroki Yamamoto Assistant Professor
Graduate School of Human & Environmental Studies
Kyoto University
Outline

We will develop a device termed “hapticsmesh” based on a flexible array of ultra-thin vibrating elements and run a psychophysical experiment to evaluate the tactile sensation produced by the hapticsmesh. We will then measure cerebro-spinal activity the somatosensory networks in humans receiving the tactile sensation alone or in combination with other types of stimuli. To help the interpretation of this measurement, we will create a probabilistic map of the somatosensory networks in the brainstem. In the somatosensory cortex, we will try to measure cortical layer-specific activity related to tactile perception. Eventually we will try to open a new venue of tactile study by developing a multi-sensory augmented reality system.

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