[Innovative reactions] Year Started : 2019

Hajime Ito

Solid-state organic synthesis with redox mechanochemistry

Research Director
Hajime Ito

Professor
Faculty of Engineering, Division of Chemical Process Engineering
Hokkaido University

Collaborator
Takaya Hikaru Professor
School of Biological and Environmental Science
Teikyo University of Science
Satoshi Maeda Professor
Faculty of Science, Department of Chemistry
Hokkaido University
Akiko Yagi Designated Associate Professor
Institute of Transformative bio-Molecules
Nagoya University
Outline

Synthetic organic chemistry provides advanced materials necessary for mankind such as pharmaceuticals and electronic materials, but the use of organic solvents is a bottleneck in terms of environmental impact and cost. In this study, we will establish “solid organic synthetic chemistry” that does not use organic solvents, using a new technology called “redox mechanochemistry” developed by us. This research not only reduces the cost of organic synthesis, but also enables the development of new materials that have not been studied due to their low solubility.

Kazuhiro Chiba

Dehydration-condensation reaction by electron transfer control

Research Director
Kazuhiro Chiba

President
Tokyo University of Agriculture and Technology

Collaborator
Masanobu Uchiyama Professor
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Akio Saito Professor
Institute of Global Innovation Research
Tokyo University of Agriculture and Technology
Outline

In this project, we construct an electron relay system that promotes the generation and reaction of open-shell molecules to achieve an electron-transfer dehydration-condensation method. By using wide variety of medium molecule peptides as model compounds, the system minimizes the amount of waste from chemical reactions, and built a multi-step dehydration condensation reaction system to achieve high purity and high yield production. In this way, we will fundamentally change the concept of mass consumption of reagents and reaction solutions in conventional chemical methods, and aim to develop the innovative chemical production by electron transfer and photo irradiation process.

Tomohiro Nozaki

Developing nonthermal plasma enabled electron-driven catalysis

Research Director
Tomohiro Nozaki

Professor
School of Engineering
Tokyo Institute of Technology

Collaborator
Hyunha Kim Leader
Environmental Management Research Institute
National Institute of Advanced Industrial Science and Technology
Satoru Takakusagi Associate Professor
Institute for Catalysis
Hokkaido University
Outline

We will conduct the multidisciplinary academic research to elucidate the origins of plasma-interacting catalytic reaction by focusing on plasma-generated known radicals coupled with single-crystal model catalysts. Plasma-interacting catalytic reaction is diagnosed by various operando spectroscopy to exploring plasma-enabled peculiar reaction paths that support emerging catalysts development. Furthermore, we study plasma catalysis of methane reforming employing newly developed catalysts and extract the prospective candidates that reduce the characteristic temperature by 150 degC compared to the thermal catalysis. Innovative plasma catalysis, including catalysts development, that further reduces the characteristic temperature by 200 degC will be proposed.

Hideki Yorimitsu

Creation of advanced multi-functionalization reactions by means of electron injection into unsaturated bonds

Research Director
Hideki Yorimitsu

Professor
Graduate School of Science
Kyoto University

Collaborator
Shinobu Aoyagi Professor
Graduate School of Sciences
Nagoya City University
Takahiro Sasamori Professor
Faculty of Pure and Applied Sciences
University of Tsukuba
Outline

By exploring appropriate electrophiles, we will control electron injection into unsaturated bonds and create innovative reactions that introduce various functional groups to unsaturated compounds at once to provide libraries of useful synthetic intermediates and products. With the aid of crystal structure analysis and computational chemistry, we will elucidate the properties of key intermediates and reaction mechanisms and lead to further discovery of new reactions. We will also establish the use of electrolytic reduction in this project to provide innovative technology using electrical energy.

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