[Tomoko Yoshino] Construction of a platform for nucleic acid analysis of a single CTC toward anticancer drug development


Research Director

Tomoko Yoshino

Tomoko Yoshino

Institute of Engineering, Tokyo University of Agriculture and Technology
Associate Professor
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Outline

Circulating tumor cells (CTCs) are rare cells found in peripheral blood of metastatic cancer patients. Analysis of CTCs has clinical potentials of cancer patient prognosis and therapeutic effects of anticancer drug. Thus, CTCs are well recognized as useful biomarker for cancer diagnosis and potential target of drug discovery for metastatic cancer. Especially nucleic acid analysis’s such as genomic DNA or RNA of CTCs could significantly facilitate the anticancer drug development as well as the selection of efficient agents for chemotherapy. In this study, we aimed to construct the platform for a high throughput nucleic acid analysis system of CTCs at a single cell level and to propose the platform as a powerful tool for anticancer drug development.

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