The Creation of Basic Medical Technologies to Clarify and Control the Mechanisms Underlying Chronic Inflammation

Outline

The purpose of this research is to elucidate the mechanisms through which inflammation becomes chronic, and the creation of basic technologies for the early detection, control, resolution, and reparation of chronic inflammation.
More specifically, this involves research aimed at
1) identifying factors that induce and maintain the chronicity of inflammation by determining failure mechanisms of inflammation control;
2) clarifying the mechanisms through which specific diseases (including cancer, degenerative neurological disorders, and arteriosclerotic diseases) develop as a result of chronic inflammation, and to create basic technologies to control them; and
3) creating basic technologies that allow the early detection and quantitative assessment of chronic inflammation. This not only involves established basic or clinical research, but also emphasizes on research that sufficiently sublimes evidence-based findings for understanding high-dimensional inflammation control mechanisms, and leads to the development of new preemptive basic medical technologies.

Strategic Sector

Creation of basic medical technologies for the prevention, diagnosis and treatment of cancer, arteriosclerotic diseases, and autoimmune disorders by the elucidation of the mechanisms underlying chronic inflammation

Research Projects

Year Started : 2011
Research Director	Affiliation	Research Project
Issei Komuro	Professor, Osaka University	Pathophysiological role of chronic inflammation in aging-associated diseases
Toshinori Nakayama	Professor, Chiba University	Regulation of chronic inflammation and the development of new strategies for treating airway inflammatory diseases
Osamu Nureki	Professor, The University of Tokyo	Structural basis for the pathogenic disease mechanisms caused by chronic inflammation
Mitsuru Matsumoto	Professor, Tokushima University	Control of chronic inflammation through elucidation of organ-specific autoimmune disease mechanisms
Kouji Yasutomo	Professor, Tokushima University	Identification of critical genes involved in the pathogenesis of human chronic inflammatory diseases
Masayuki Yamamoto	Professor, Tohoku University	Protective mechanisms against environmental stresses leading to therapeutic strategies for chronic inflammation

Year Started : 2010
Research Director	Affiliation	Research Project
Hiroshi Asahara	Professor, Tokyo Medical and Dental University	Regulation of inflammation time axis at RNA level
Masaru Ishii	Professor, Osaka University	Next-generation imaging technology dissecting in vivo mode of action of chronic inflammatory macrophages
Kazuhide Inoue	Professor, Kyushu University	The research for the mechanism of chronically intractable pain based on the functions of microglia as brain immunocompetent cell
Hiroshi Kiyono	Professor, The University of Tokyo	Understanding of chronic inflammation for the development of new therapeutic strategies for intestinal inflammatory diseases
Takashi Nagasawa	Professor, Kyoto University	The role of microenvironmental niches for hematopoiesis in chronic inflammation
Shuh Narumiya	Professor, Kyoto University	Prostaglandin-mediated mechanisms of initiation and progression of chronic inflammation
Kouji Matsushima	Professor, The University of Tokyo	Molecular and cellular bases of chronic inflammation associated-organ fibrosis

Research Area Website: http://www.inflammation.jst.go.jp/?lang=en