Next-generation imaging technology dissecting in vivo mode of action of chronic inflammatory macrophages

Research Project Outline

Chronic inflammation has been shown to be causative of various adult diseases such as metabolic syndrome and cancer. By exploitng biological imaging technologies this study analyzes crucial roles of tissue-resident macrophages in chronic inflammation. Several novel methodologies, such as for detecting phenotypical changes in situ and for manipulating cell function by light at single cell levels, are to be developed, dissecting in vivo mode of action of macrophages under pathophysiological conditions. This study leads to the discovery of novel concepts on controlling chronic inflammation, which is surely conducive to development of revolutionary therapeutics against diverse common diseases in future.

Related Links

• Laboratory Website: http://bioimaging.ifrec.osaka-u.ac.jp/