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Understanding of chronic inflammation for the development of new therapeutic strategies for intestinal inflammatory diseases

Research Project Outline

The healthy intestinal tract is maintained by the highly sophisticated homeostatic mechanism operating between symbiotic bacteria and mucosal immune cells, and collapse of this mutually beneficial mucosal bidirectional interaction system leads to the development of refractory chronic inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. In this project, through investigating the cellular and molecular mechanisms of intestinal homeostatic and pathological inflammations by meaning of the contribution made by the symbiotic cohabiting microflora, the carbohydrate-chains on epithelial cells, and the innate immune cells at the intestinal mucosa, we aim to develop new treatments, preventions and diagnostic methods for intestinal inflammatory diseases.

Research Director
Professor, The University of Tokyo
Research Started
Research Area
The Creation of Basic Medical Technologies to Clarify and Control the Mechanisms Underlying Chronic Inflammation
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Research Areas Completed
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