HOME > Research Areas by Category > Creation of a Novel...

Creation of a Novel Technology towards Diagnosis and Treatment based on Understanding of Molecular Pathogenesis of Psychiatric and Neurological Disorders

Research Supervisor
Teruhiko Higuchi
President, National Center of Neurology and Psychiatry
Year Started


Psychiatric and neurological disorders attributable to disorders of higher brain functions, such as cognition and emotion, are an issue of high social demand in Japan, which is increasingly affected by a declining birthrate, aging, and social tension. This Research Area aims at the creation of a novel technology for prevention, diagnosis, and therapy for psychiatric and neurological disorders.More specifically, it targets research towards evidence-based objective diagnosis and curative therapy based on the understanding of molecular pathogenesis of psychiatric and neurological disorders that engender higher brain function disorders. Exemplary research objects include: development of diagnostic methods using, for example, biological markers, which are available as an objective index from biochemical or molecular genetic points of view, or functional markers such as non invasive brain imaging technology; analysis of animals used in disease modeling reproducing gene mutation or environmental change;and search for and identification of target molecules towards innovative drug development for implementing basic treatment. This Research Area also deems important those studies that aim at organic fusion of different research areas or study methods, including clinical study for disorders vs. fundamental study like brain science, psychiatric disorder study vs. neurological disorder study, and intermediate phenotype analysis studies like brain imaging vs. gene analysis study, to advance these studies.

Strategic Sector

Creation of Innovations toward the Development of Diagnosis and Treatment of Psychiatric and Neurological Disorders based on Elucidation of Complex and Higher Brain Functions

Research Projects

Year Started : 2007
Research Director Affiliation Research Project
Kaoru Inokuchi Professor, University of Toyama Development of PTSD Remedy based on the Molecular Mechanisms underlying Fear Memory Formation
Takeshi Iwatsubo Professor, The University of Tokyo Comprehensive Study for the Development of Disease-modifying Therapies for Alzheimer's Disease
Kozo Kaibuchi Professor, Nagoya University Elucidation of Molecular Pathogenesis of Schizophrenia by Analyzing Susceptibility Genes
Ryosuke Takahashi Professor, Kyoto University Elucidation of Parkinson's Disease (PD) Gene Networks and Establishment of Strategies for Treating PD
Tsuyoshi Miyakawa Professor, Fujita Health University Identification of Endophenotype in Psychiatric Disorders using Genetically Engineered Mice
Research Areas by Category
Research Areas Completed
Researcher Index