Research Project Outline
Amyotrophic lateral sclerosis (ALS) is sporadic in over 90% cases. Its pathogenesis remains largely elusive and the basic remedy for this disease is not established so far. In this CREST project we will develop animal models mimicking molecular events observed in the pathological tissues of sporadic ALS patients and clarify molecular pathogenesis and target mol-ecules leading to motor neuron degeneration. Moreover we will develop molecular targeted therapy and aim for its clinical application.