Research Project Outline
Cerebellar Purkinje cell(PC) impairment cause spinocerebellar ataxiass (SCAs) but there has been few treatments. In this research, we plan to elucidate pathologic pathways from RNA expression to individual disease onset as well as to establish a treatment strategy through development of animal models imitating genetic SCAs with PC degenaration, and omics and chemical biology techniques. We would finally like to create treatment methods and diagnostic markers which could be applicable to PC impairment and cerebellar ataxia in general.