論文・成果
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*Nagao, A., Nakanishi, Y., Yamaguchi, Y., Mishina, Y., Karoji, M., Toya, T., Fujita, T., Iwasaki, S., Miyauchi, K., Sakaguchi, Y. and *Suzuki, T. Quality control of protein synthesis in the early elongation stage Nature Communications, 14, 2704(2023) -
Ogawa, A., Ohira, S., Kato, Y., Ikuta, T., Yanagida, S., Mi, C., Ishii, Y., Kanda, Y., Nishida, M., Inoue, A. and Wei, FY. Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction Communications Biology, 6, 511(2023) -
Nakagawa, R., Hirano, H., Omura, S.N., Nety, S., Kannan, S., Altae-Tran, H., Yao, X., Sakaguchi, Y., Ohira, T., Wu, W.Y., Shuto, Y., Tanaka, T., Sano, F.K., Kusakizako, T., Kise, Y., Ito, Y., van der Oost, J., Suzuki, T., Zhang, F. and *Nureki, N. Cryo-EM structure of the transposon-associated TnpB enzyme Nature, 616, 390-397(2023) -
*Suzuki, T., *Yi, C. and Song, J. Wolf Prize in Chemistry 2023: A Celebration for Chemical Biology ACS Chemical Biology, 18, 671-673(2023) -
Matsumura Y, Wei FY, Sakai J. Epitranscriptomics in metabolic disease Nature Metabolism, 5, 370-384(2023) -
Murakami Y, Wei FY, Kawamura Y, Horiguchi H, Kadomatsu T, Miyata K, Miura K, Oike Y, Ando Y, Ueda M, Tomizawa K, Chujo T. NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice. Commun Biol., 6, 307(2023) -
Yamazaki H.* and Kan S. Accelerating biophysical studies and applications by label-free nanopore sensing Biophysics and Physicobiology, 20, e200010(2023) -
Ueda, H., Dasgupta, B., Yu, B. RNA Modification Detection Using Nanopore Direct RNA Sequencing and nanoDoc2 Methods in Molecular Biology, 2632, 299-319(2023) -
Tomoda, E., Nagao, A.*, Shirai, Y., Asano, K., Suzuki, T., Battersby, B. and Suzuki, T.* Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases Nucleic Acids Res.(2023) -
Ohno, H., Akamine, S., Mochizuki, M., Hayashi, K., Akichika, S.,Suzuki, T. and Saito, H.* Versatile strategy using vaccinia virus-capping enzyme to synthesize functional 5' cap-modified mRNAs Nucleic Acids Res.(2023) -
Nagayoshi Y, Nishiguchi K, Yamamura R, Chujo T, Oshiumi H, Nagata H, Kaneko H, Yamamoto K, Nakata H, Sakakida K, Kunisawa A, Adachi M, Kakizoe Y, Mizobe T, Kuratsu JI, Shimada S, Nakamori Y, Matsuoka M, Mukoyama M, Wei FY, Tomizawa K*. t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and Severity. Biomolecules, 12, 1233 (2022) -
Iizuka R.+,Yamazaki H.+ and Uemura S.* (+ equal contribution) Zero-mode waveguides and nanopore-based sequencing technologies accelerate single-molecule studies Biophysics and Physicobiology, 19, e190032 (2022) -
Tani, H., Ishikawa, K., Tamashiro, H., Ogasawara, E., Yasukawa, T., Matsuda, S., Shimizu, A., Kang, D., Hayashi, JI.,Wei, FY. and Nakada, K.* Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation Nucleic Acids Res., 50(16), 9382-9396 (2022) -
Noda, Y., Okada, S. and Suzuki, T.* Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis Nature Communications, 13, 2503 (2022) -
Ohira, T.+,*, Minowa, K.+, Sugiyama, K., Yamashita, S., Sakaguchi, Y., Miyauchi, K., Noguchi, R., Kaneko, A., Orita, I., Fukui, T., Tomita, K.* and Suzuki, T.* (+ equal contribution) Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance Nature, 605, 372-379 (2022) -
Monde, K.,*, Satou, Y., Goto, M., Uchiyama, Y., Ito, J., Kaitsuka, T., Terasawa, H., Monde, N., Yamaga, S., Matsusako, T.,Wei, FY., Inoue, I., Tomizawa, K., Ono, A., Era, T., Sawa, T. and Maeda, Y. Movements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells J Virol., 96(9), e0035622 (2022)
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Yakita, M., Chujo, T.,*,Wei, FY., Hirayama, M., Kato, K., Takahashi, N., Naganuma, K., Nagata, M., Kawahara, K., Nakayama, H.and Tomizawa, K.* Extracellular N6 -isopentenyladenosine (i6A) addition induces cotranscriptional i6A incorporation into ribosomal RNAs RNA, 28(7), 1013-1027 (2022)
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Wang, J., Yashiro, Y., Sakaguchi, Y., Suzuki, T. and Tomita, K.* Mechanistic insights into tRNA cleavage by a contact-dependent growth inhibitor protein and translation factors Nucleic Acids Research, 50(8) (2022)
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Yashiro,Y., Zhang,C., Sakaguchi,Y.,Suzuki, T. and Tomita, K.* Molecular basis of glycyl-tRNAGly acetylation by TacT from Salmonella Typhimurium Cell Reports, 37, 110130(2021)
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Fradejas-Villar, N., Bohleber, S., Zhao, W., Reuter, U., Kotter, A., Knoll, R., Helm, M., McFarland, R., Taylor, R.W., Mo, Y., Miyauchi, K., Sakaguchi, Y., Suzuki, T. and Schweizer, U.* The effect of tRNA[Ser]Sec isopentenylation on selenoprotein expression International Journal of Molecular Sciences, 22(21), 11454 (2021)
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Ogawa,A.* and Wei, FY.* Protocol for preparation and measurement of intracellular and extracellular modified RNA using liquid chromatography-mass spectrometry STAR Protoc., 2(4), 100848(2021)
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Roni Rak, R., Polonsky, M., Eizenberg, I., Mo, Y., Sakaguchi, Y., Mizrahi, O., Nachshon, A., Reich-Zeliger, S., Stern-Ginossar, N., Dahan, O., Suzuki, T., Friedman, N. and Pilpel, Y. Dynamic changes in tRNA modifications and abundance during T-cell activation Proceedings of the National Academy of Sciences of USA., 118(42), e2106556118 (2021)
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Shi, SL., Fukuda, H., Chujo, T., Kouwaki, T., Oshiumi, H., Tomizawa, K.* and Wei, FY.* Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication. RNA Biol., 18, 478-495 (2021)
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Kurata, T.*, Brodiazhenko, T., Oliveira, S. R. A., Roghanian, M., Sakaguchi, Y., Turnbull, K. J., Bulvas, O., Takada, H., Taman, H., Ainelo, A., Pohl, R., Rejman, D., Tenson, T., Suzuki, T., Garcia-Pino, A., Atkinson, G. C.* and Hauryliuk, V* RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis Mol Cell, 81, 3160-3170 (2021) -
Ninomiya, K., Iwakiri, J., Kharmis Aly, K., Sakaguchi, Y., Adachi, S., Natsume, T., Terai, G., Asai, K., Suzuki, T. and Hirose, T.* m6A modification of HSATIII lncRNAs regulates temperature-dependent splicing EMBO J., 40, e107976 (2021) -
Akichika, S., Suzuki, T. and Suzuki, T.* Mass spectrometric analysis of mRNA 5’ terminal modifications Methods in Enzymol., 658, 407-418 (2021)
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Watabe, E., Togo-Ohno, M., Ishigami, Y., Wani, S., Hirota, K., Kimura-Asami, M., Hasan, S., Takei, S., Fukamizu, A., Suzuki, Y., Suzuki, T. and Kuroyanagi, H.* m6A-mediated alternative splicing coupled with nonsense-mediated mRNA decay regulates SAM synthetase homeostasis EMBO J., 40, e106434 (2021) -
Ishigami, Y., Ohira, T., Isokawa, Y., Suzuki, Y. and Suzuki, T.* A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site Nature Commun., 12, 3244 (2021) -
Suzuki, T.* and Nagao, A. Genetic code and its variations Encyclopedia of Life Sciences (eLS), 2, 147-157 (2021)
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Nagayoshi, Y.+, Chujo, T.+, Hirata, S., Nakatsuka, H., Chen, C.W., Takakura, M., Miyauchi, K., Ikeuchi, Y., Carlyle, B.C., Kitchen, R.R., Suzuki, T., Katsuoka, F., Yamamoto, M., Goto, Y., Tanaka, M., Natsume, K., Nairn, A.C., Suzuki, T., Tomizawa, K.* and Wei, FY.* (+ equal contribution) Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability Science Advances, 7, eabf3072 (2021) -
Suzuki, T.* The expanding world of tRNA modifications and their disease relevance Nature Reviews Molecular Cell Biology, 22, 375–392 (2021) -
Ogawa, A., Nagiri, C., Shihoya, W., Inoue, A., Kawakami, K., Hiratsuka, S., Aoki, J., Ito, Y., Suzuki, T., Suzuki, T., Inoue, T., Nureki, O., Tanihara, H., Tomizawa, K. and Wei, FY.* N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand Mol Cell, 81, 659-674 (2021) -
Ishigami, Y., Suzuki, T.* and Suzuki, T.* Mass spectrometric analysis of mitochondrial RNA modifications Methods in Mol Biol, 2192, 89-101 (2021)
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Yashiro, Y., Sakaguchi, Y., Suzuki, T., and Tomita, K.* Mechanism of aminoacyl-tRNA acetylation by an aminoacyl-tRNA acetyltransferase AtaT from enterohemorrhagic E. coli Nature Commun., 11, 5438 (2020)
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Kurimoto, R., Chiba, T., Ito, Y., Matsushima, T., Yano, Y., Miyata, K., Suzuki, T., Tomita, K. and Asahara, H.* The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA EMBO J., 39, e104708 (2020)
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Ueda, H.* nanoDoc: RNA modification detection using Nanopore raw reads with Deep One-Class Classification bioRxiv, doi: 10.1101/2020.09.13.295089 (2020)
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