【Introduction】

Our lives are sustained through the utilization the bio-energy generated by carbohydrates and oxygen reacting by the metabolic system; at the same time, this process serves as a warning system against stimuli from the outside world. NO, CO, H₂S are well-known as low-molecular weight gas mediators that are generated from the end of the metabolic system; these gas molecules may work as an important control factor over the metabolic system by regulating the functions of proteins that possess a metallic center such as enzymes. The significant dependency of the redox state of the metallic center on the bonding state of gases however, has rendered the understanding of gas molecule behavior in the body extremely difficult, and likewise the identification of receptors, or functional assessment, thus relegating the clarification of the complete picture, or its potential application to the control of pathological conditions to an unknown area. Molecular biology, biochemistry, computer science, physics and others should be included to organize an interdisciplinary research team integral to solving such challenges, together with the application of state-of-the-art measurement science. The Suematsu Gas Biology Project will promote a project aiming for comprehensive explanation of the acceptance, transportation, and decomposition mechanisms of the gas molecules produced and utilized in the body and applying the results to Medicine.

March, 1983	Graduated from the School of Medicine, Keio University
April, 1984	Entered the Graduate School of Medicine, Keio University (majored in Internal Medicine)
March, 1988	Left the Graduate School of Medicine, Keio University with required courses completed
April, 1988	Assistant at Keio University (Department of Internal Medicine, School of Medicine)
January, 1990	Assistant at Keio University (Central Clinical Examination Department, School of Medicine)
May, 1991	Assistant at Keio University (Department of Internal Medicine, School of Medicine) After return to the department, immediately went to the Institute for Biomedical Engineering, University of California, San Diego (Supervised by Professor Benjamin W. Zweifach).
April, 1996	Assistant Professor of Keio University (Department of Biochemistry and Integrative Medical Biology, School of Medicine)
April, 2001	Professor of Keio University (Department of Biochemistry and Integrative Medical Biology, School of Medicine)
October, 2002	Project operator for hub formation in 21st Century COE Life Science "Understanding and Management of Life Function through System Biology"
January, 2003	Professor of Environment and Information Studies of Keio University (interlocking)
April, 2003	Representative researcher, the Leading Project for Biosimulation by the Ministry of Education, Culture, Sports, Science and Technology of Japan
June, 2005	Member of Committee of Life Science, Ministry of Education, Culture, Sports, Science and Technology of Japan Steering committee Research and Development of Integrated Simulation Software for Next Generation Life Form, RIKEN Base representative for Bases of In vivo Human Metabolic Systems Biology by the Ministry of Education, Culture, Sports, Science and Technology of Japan COE for Life Science Head, Center for Human Metabolic Systems Biology
October, 2007	Dean, School of Medicine, Keio University

1984 to present	Japanese Society for Microcirculation (Director)
1984 to present	The Japanese Society of Gastroenterology
1988 to present	The European Microcirculatory Society
1989 to present	The Microcirculatory Society USA
1991 to present	The Oxygen Societ
1992 to present	The Japanese Biochemical Society (Councilor, Chief of Kanto Branch)
1994 to present	American Association for the Study of Liver Diseases
1995 to present	The Society of Blood Substitutes, Japan (Director)
2001 to present	American Society for Biochemistry and Molecular Biology and more, including editorial committee of English journals (Am J Physiol, Antioxid Redox Signal, etc.)

1990	Young Investigator's Award from The 14th Microcirculatory Society, Europe
1990	Incentive Award from the 30th Science and Technology Film Festival
1992	Certificate of Appreciation from Mexican Society of Anesthesiologists (for the research of free radical bioimaging)
1994	Lafon Microcirculatory Award from the 16th European Microcirculatory Society Conference
2004	American Physiology Society/The Microcirculatory Society 50th Anniversary Selected as Historical Poster (Free Radical Bioimaging in Microcirculation)
2010	Society for Free Radical Research JAPAN

1984	Completed the doctoral course (medicine, genetics), University of Pennsylvania
1986	Resident (pediatrics), Duke University Medical Center
1990	Post-doctoral fellow, Johns Hopkins University (clinical genetics)
1994 to 1999	Associate professor, Johns Hopkins University (pediatrics)）
1999	Professor, Genetics and Medical Institute, Johns Hopkins University
2003 to present	rofessor, Johns Hopkins University (pediatrics) Director of Vascular Cell Engineering Program, Institute for Cell Engineering, Johns Hopkins University