ERATO 浜地ニューロ分子技術プロジェクト

menu

総説

2025年

  • Selective Labeling of Phosphatidylcholine to Track Their Translocation Between Organelles in Living Cells
    Tomonori Tamura and Itaru Hamachi
    Intracellular Lipid Transport, 2025, 1, 1-11. eBook ISBN 978-1-0716-4318-1
  • Targeted Covalent Modification Strategies for Drugging theUndruggable Targets
    Tomonori Tamura, Masaharu Kawano and Itaru Hamachi
    Chemical Reviews, 2025, 125, 1191-1253. doi: 10.1021/acs.chemrev.4c00745
  • N‑Acyl‑N‑alkyl/aryl Sulfonamide Chemistry Assisted by Proximity forModification and Covalent Inhibition of Endogenous Proteins inLiving Systems
    Tomonori Tamura and Itaru Hamachi
    Accounts of Chemical Research, 2025, 58, 87-100. doi: 10.1021/acs.accounts.4c00628

    • 2024年

    • Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging
      Takeharu Mino, Hiroshi Nonaka and Itaru Hamachi
      Current Opinion in Chemical Biology, 2024, 81, 102474. DOI: 10.1016/j.cbpa.2024.102474
    • The hidden face of GluD1 at inhibitory synapses
      Masayuki Itoh and Michisuke Yuzaki
      Cell Research, 2024, 34, 405–406. https://doi.org/10.1038/s41422-024-00931-6
    • 組織内の小分子を可視化するFixEL
      美野 丈晴、野中 洋、浜地 格
      生体の科学, 2024, 75, 1, 84-89. free access

      • 2023年

      • Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems
        Ryou Kubota and Itaru Hamachi
        Advanced Science, 2023, 2306830. https://doi.org/10.1002/advs.202306830
      • 高次脳機能の理解に向けた分子標的ケモジェネティクス法の開発
        清中 茂樹, 堂浦 智裕
        MEDCHEM NEWS, 2023, 33, 136-141
      • 細胞種選択的なグルタミン酸受容体の活性化手法「配位ケモジェネティクス」の開発
        清中 茂樹, 鈴木 啓文
        生物物理, 2023, 63, 157-159
      • 高次脳機能の理解に向けた次世代ケモジェネティクス法の開発
        松岡 佑真, 柏 俊太朗, 堂浦 智裕, 清中 茂樹
        Brain and NERVE, 2023, 75, 367-374
      • Protocol to visualize the distribution of exogenously administered small molecules in the mouse brain
        Takeharu Mino, Hiroshi Nonaka, Seiji Sakamoto, Jae Hoon Oh and Itaru Hamachi
        STAR Protocols, 2023, 4, 3, 102555. doi:10.1016/j.xpro.2023.102555
      • Flow cytometric analysis of phosphatidylcholine metabolism using organelle-selective click labeling
        Masaki Tsuchiya, Nobuhiko Tachibana and Itaru Hamachi
        STAR Protocols, 2023, 4, 3, 102525. doi:10.1016/j.xpro.2023.102525
      • Glial regulation of circuit dynamics and animal behavior
        Jun Nagai and Tetsuya Takano
        Neuroscience Research, 2023, 187, 1-2. https://doi.org/10.1016/j.neures.2023.01.005
      • シナプスオーガナイザー Extracellular scaffolding protein
        野澤 和弥,柚﨑 通介
        生体の科学, 74, 1, 3-7
      • 化学で脳を理解するための新技術「配位ケモジェネティクス」
        三浦 裕太, 清中 茂樹
        化学, 78, 24-29
      • Ligand-Directed Chemistry for Protein Labeling for Affinity-Based Protein Analysis
        Seiji Sakamoto and Itaru Hamachi
        Israel Journal of Chemistry, 2023, e202200077. doi.org/10.1002/ijch.202200077

      2022年

      • Chemical biology tools for imaging-based analysis of organelle membranes and lipids
        Tomonori Tamura and Itaru Hamachi
        Current Opinion in Chemical Biology 2022, 70:102182. https://doi.org/10.1016/j.cbpa.2022.102182
      • 配位ケモジェネティクスによるグルタミン酸受容体の活性制御
        三浦 裕太, 小島 憲人, 清中 茂樹
        日薬理誌, 157, 366-370
      • リガンド指向性2段階ラベル化によるAMPA型グルタミン酸受容体の精密動態解析
        杉原 佑太朗, 小島 憲人, 清中 茂樹
        日薬理誌, 157, 191-195
      • 迅速ケミカルラベル化法によるAMPA型グルタミン酸受容体の精密動態解析
        曽我 恭平, 清中 茂樹
        生化学, 94, 292-297
      • 配位ケモジェネティクスによる代謝型グルタミン酸受容体の制御
        妹尾 暁暢, 清中 茂樹
        化学と工業, 75, 11
      • Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches
        Yuta Miura, Akinobu Senoo, Tomohiro Doura and Shigeki Kiyonaka
        RSC Chem. Biol., 2022, 3, 269-287. https://doi.org/10.1039/D1CB00195G

        • 2021年

        • Purkinje Cell Dendrites: The Time-Tested Icon in Histology
          Yukari H. Takeo and Michisuke Yuzaki
          Cerebellum as a CNS Hub, 145-167. doi: 10.1007/978-3-030-75817-2_7
        • Tethering-based chemogenetic approaches for the modulation of protein function in live cells
          Yu-Hsuan Tsai, Tomohiro Doura and Shigeki Kiyonaka
          Chem. Soc. Rev., 2021, 50, 7909-7923. doi:10.1039/d1cs00059d
        • GPCRおよびGタンパク質シグナルを特異的に制御するケモジェネティクス法
          三浦 裕太、清中 茂樹
          細胞, 53, 5, 328-330
        • アストロサイトに見つかった抑制性シナプス制御機能
          髙野 哲也
          Nature ダイジェスト, 18, 4  doi : 10.1038/ndigest.2021.210434
        • 新たな近位依存性ビオチン標識Split-TurboID法が導く三者間シナプスの役割と機能
          髙野 哲也
          実験医学 39, 6
        • Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies
          Ryou Kubota, Wataru Tanaka and Itaru Hamachi
          Chem. Rev., 2021, 121, 22, 14281−14347. https://doi.org/10.1021/acs.chemrev.0c01334
        • Organelle-Selective Labeling of Choline-Containing Phospholipids (CPLs)and Real-Time Imaging in Living Cells
          Masaki Tsuchiya, Tomonori Tamura and Itaru Hamachi
          Current Protocols, 2021, 1, e105. doi: 10.1002/cpz1.105
        • 中枢神経系におけるグルタミン酸受容体と分泌型シナプス形成因子のクロストーク
          松田 恵子
          ブレインサイエンス・レビュ―2021
        • 小脳LTD/LTPー 小脳学習を支えるシナプス可塑性
          掛川 渉、柚﨑 通介
          生体の科学, 72, 1, 23-29
        • Recent applications of N-acyl imidazole chemistry in chemical biology
          Takeharu Mino, Seiji Sakamoto and Itaru Hamachi
          Bioscience, Biotechnology, and Biochemistry, 2021, 85, 1, 53-60. doi:10.1093/bbb/zbaa026

        2020年

        • Fluorescence imaging of drug target proteins using chemical probes
          Hao Zhu and Itaru Hamachi
          Journal of Pharmaceutical Analysis, 2020, 10, 5, 426-433. doi:10.1016/j.jpha.2020.05.013
        • Synaptic Function and Neuropathological Disease Revealed by Quantum Dot-Single-Particle Tracking
          Hiroko Bannai, Takefumi Inoue, Matsumi Hirose, Fumihiro Niwa and Katsuhiko Mikoshiba
          Single Molecular Microscopy in Neurobiology, 2020, 154, 131-155. doi:10.1007/978-1-0716-0532-5_7
        • Chemical Tools for Endogenous Protein Labeling and Profiling
          Kazuki Shiraiwa, Rong Cheng, Hiroshi Nonaka, Tomonori Tamura and Itaru Hamachi
          Cell Chemical Biology, 2020, 27, 8, 970-985. doi:10.1016/j.chembio|.2020.06016
        • The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels
          Ryou Kubota, Keisuke Nakamura, Shogo Torigoe and Itaru Hamachi
          ChemistryOPEN, 2020, 9, 67-79. doi:10.1002/open.201900328

        2019年

        • 小脳学習における長期抑圧 (LTD) の役割
          掛川 渉、松田 信爾、柚﨑 通介
          Clinical Neuroscience, 2019, 37, 919-924.
        • On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells
          Ryou Kubota, Shigeki Kiyonaka and Itaru Hamachi
          Methods in Enzymology, 2019, 622, 411-430. doi: 10.1016/bs.mie.2019.02.033
        • Construction of ligand assay systems by protein-based semisynthetic biosensors
          Seiji Sakamoto, Shigeki Kiyonaka and ItaruHamachi
          Current Opinionin Chemical Biology, 2019, 50, 10-18. https://doi.org/10.1016/j.cbpa.2019.02.011
        • Recent Progress in Chemical Modification of Proteins
          Seiji Sakamoto and Itaru Hamachi
          Analytical Sciences, 2019, 35, 1, 5-27. https://doi:10.2116/analsci.18R003