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磯部 寛之 大谷 啓太 大友 明 大野 雄高 高村 禅 塚越 一仁 舟窪 浩
研究者紹介
 
生体・溶液系ナノデバイス研究の為の微小流体チップ開発
高村 禅 (たかむら ゆずる)
(北陸先端科学技術大学院大学 材料科学研究科 助教授)

生年 1966年
出身地 石川県
学歴
 
1990年3月 東京大学工学部金属材料学科 卒業
1990年4月 東京大学大学院工学系研究科超伝導工学専攻修士課程 入学
1992年3月 東京大学大学院工学系研究科超伝導工学専攻修士課程 修了
1992年4月 東京大学大学院工学系研究科金属工学専攻博士課程 入学
1995年3月 東京大学大学院工学系研究科金属工学専攻博士課程 修了 博士(工学)

職歴
 
1993年4月 日本学術振興会 特別研究員
1996年6月 文部省宇宙科学研究所 助手
1999年2月 東京大学大学院工学系研究科 助手
2003年4月 北陸先端科学技術大学院大学 助教授

研究歴
 
1989年4月〜 ボロン系半導体準結晶の探索
1990年4月〜 熱プラズマによる酸化物超伝導体の高速エピタキシャル成長
1996年6月〜 半導体とセラミックスの無容器大過冷凝固の研究
1999年2月〜 半導体微細加工技術を応用したヘルスケアチップ開発
2003年4月〜 微小流体デバイス研究
 
発表論文リスト >>>さきがけ研究
 
[1] K. Kerman, Y. Morita, Y. Takamura, E. Tamiya
Escherichia coli single-strand binding protein-DNA interactions on carbon nanotube-modified electrodes from a label-free electrochemical hybridization sensor
Analytical and Bioanalytical Chemistry 381, 1114-1121 (2005) .

[2] K. Kerman, Y. Morita, Y. Takamura, E. Tamiya, K. Maehashi, K. Matsumoto
Peptide Nucleic Acid-Modified Carbon Nanotube Field-Effect Transistor for Ultra-Sensitive Real-Time Detection of DNA Hybridization
Nanobiotechnology 1, 65-70 (2005) .

[3] K. Kerman, Y. Matsubara, Y. Morita, Y. Takamura, E. Tamiya
Peptide nucleic acid modified magnetic beads for intercalator based electrochemical detection of DNA hybridization
Sci. Technol. Adv. Mater. 5, 351-357 (2004) .

[4] K. Kerman, Y. Morita, Y. Takamura, M. Ozsoz, E. Tamiya
Modification of Escherichia coli single-stranded DNA binding protein with gold nanoparticles for electrochemical detection of DNA hybridization
Anal. Chim. Acta 510, 169-174 (2004) .

[5] K. Kerman, Y. Morita, Y. Takamura, M. Ozsoz, E. Tamiya
DNA-directed attachment of carbon nanotubes for enhanced label-free electrochemical detection of DNA hybridization
Electroanal. 16, 1667-1672 (2004) .

[6] K. Kerman, M. Saito, Y. Morita, Y. Takamura, M. Ozsoz, E. Tamiya
Electrochemical Coding of Single-Nucleotide Polymorphisms By Monobase-Modified Gold Nanoparticles
Anal. Chem. 76, 1877-1884 (2004) .

[7] K. Maehashi, K. Matsumoto, K. Kerman, Y. Takamura, E. Tamiya
Ultrasensitive detection of DNA hybridization using carbon nanotube field-effect transistors
Japanese Journal of Applied Physics, Part 2: Letters & Express Letters 43, L1558-L1560 (2004) .

[8] Y. Matsubara, K. Kerman, M. Kobayashi, S. Yamamura, Y. Morita, Y. Takamura, E. Tamiya
On-Chip Nanoliter-Volume Multiplex TaqMan Polymerase Chain Reaction from A Single Copy Based on Counting Fluorescence Released Microchambers
Anal. Chem. 76, 6434-6439 (2004) .

[9] Y. Murakami, T. Endo, S. Yamamura, N. Nagatani, Y. Takamura, E. Tamiya
On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506)
Anal. Biochem. 334, 111-116 (2004) .

[10] 10. M. Saito, M. Kobayashi, S.-i. Iwabuchi, Y. Morita, Y. Takamura, E. Tamiya
DNA condensation monitoring after interaction with Hoechst 33258 by atomic force microscopy and fluorescence spectroscopy
J. Biochem. (Tokyo) 136, 813-823 (2004) .

[11] M. Ueda, T. Hayama, Y. Takamura, Y. Horiike, T. Dotera, Y. Baba
Electrophoresis of long deoxyribonucleic acid in curved channels: The effect of channel width on migration dynamics
J. Appl. Phys. 96, 2937-2944 (2004) .

[12] M. Ueda, T. Hayama, Y. Takamura, Y. Horiike, T. Dotera, Y. Baba
Curvature entropy trapping of long DNA under hydrodynamic flows in microfluidic devices
Jpn. J. Appl. Phys. 43, 1649-1650 (2004) .

[13] M. Ueda, Y. Takamura, Y. Horiike, Y. Baba
Concentration and injection of long deoxyribonucleic acid molecules at the interface of micro- and nano-channels
Jpn. J. Appl. Phys. 43, 4417-4418 (2004) .

[14] K. Terashima, M. Kondoh, Y. Takamura, H. Komaki, T. Yoshida
Surface modification of Bi-Sr-Ca-Cu-O films deposited in situ by radio frequency plasma flash evaporation with a scanning tunneling microscope, Appl. Phys. Lett. 59, 644-646 (1991).

[15] Y. Hirokawa, Y. Takamura, H. Komaki, K. Terashima, T. Yoshida
Control of the preferred orientation of YBa2Cu3O7-x films by the plasma flash evaporation
J. Mater. Synth. Proc. 1, 53-60 (1993).

[16] Y. Takamura, K. Hayasaki, K. Terashima, T. Yoshida
The role of radicals and clusters in thermal plasma flash evaporation processing
Plasma Chem. Plasma Proc. 16, S141 (1996).

[17] K. Hayasaki, Y. Takamura, N. Yamaguchi, K. Terashima, T. Yoshida
Scanning tunneling microscopy of epitaxial YBa2Cu3O7-x films prepared by thermal plasma flash evaporation method
J. Appl. Phys. 81, 1222-1226 (1997).

[18] Y. Takamura, K. Hayasaki, K. Terashima, T. Yoshida
Cluster size measurement using microtrench in thermal plasma flash evaporation process
J. Vacuum Sci. Technol. B15, 558-565 (1997).

[19] T. Aoyama, Y. Takamura, K. Kuribayashi
Containerless solidification of Si-Ge binary alloy by means of laser heating electromagnetic levitation
Jpn. J. Appl. Phys. [2] Lett. 37, L687-L690 (1998).

[20] Y. Takamura, N. Yamaguchi, K. Terashima, T. Yoshida
High-rate deposition of YBa2Cu3O7-x films by hot cluster epitaxy
J. Appl. Phys. 84, 5084-5088 (1998).

[21] K. Terashima, N. Yamaguchi, T. Hattori, Y. Takamura, T. Yoshida
High rate deposition of thick epitaxial films by thermal plasma flash evaporation
Pure & Applied Chemistry 70, 1193-1197 (1998).

[22] T. Aoyama, Y. Takamura, K. Kuribayashi
Dendrite growth processes of silicon and germanium from highly undercooled melts
Metall. Mater. Trans. A 30A, 1333-1339 (1999).

[23] K. Nagashio, Y. Takamura, K. Kuribayashi
Coupled growth in the peritectic Nd-Ba-Cu-O system from highly undercooled melt
Script Mater. 41, 1161-1167 (1999).

[24] K. Nagashio, Y. Takamura, K. Kuribayashi, Y. Shiohara
Microstructure control of NdBa2Cu3O7-d superconducting oxide from the highly undercooled melt by containerless processing
J. Crystal Growth 200, 118-125 (1999).

[25] K. Terashima, Y. Taniguchi, N. Yamaguchi, Y. Takamura, T. Yoshida
Scanning tunneling microscopy operating under a plasma environment
Thin Solid Films 345, 146-150 (1999).

[26] K. Nagashio, K. Kuribayashi, Y. Takamura
Phase selection of peritectic phase in undercooled Nd-based superconducting oxides
Acta Mater. 48, 3049-3057 (2000).

[27] K. Nagashio, Y. Takamura, K. Kuribayashi
Containerless solidification of peritectic and eutectic ceramics using aero-acoustic levitator
Materials Science Forum 173-178 (2000).

[28] K. Nagashio, Y. Takamura, K. Kuribayashi
Peritectic coupled growth in Nd-based superconducting oxides from highly undercooled melt
Materials Science Forum 197-202 (2000).

[29] Y. Takamura, K. Nagashio, K. Kuribayashi
Containerless processing of Y3Fe5O12 garnet using aero-acoustic levitator
Space Forum 6, 171-177 (2000).

[30] T. Kuzumaki, Y. Takamura, H. Ichinose, Y. Horiike
Structural change at the carbon-nanotube tip by field emission
Appl. Phys. Lett. 78, 3699-3701 (2001).

[31] K. Nagashio, K. Kuribayashi, Y. Takamura
Direct crystallization of Y3Fe5O12 garnet by containerless solidification processing
Mater. Trans. 42, 233-237 (2001).

[32] A. Oki, S. Adachi, Y. Takamura, K. Ishihara, H. Ogawa, Y. Ito, T. Ichiki, Y. Horiike
Electroosmosis injection of blood serum into biocompatible microcapillary chip fabricated on quartz plate
Electrophoresis 22, 341-347 (2001).

[33] A. Oki, Y. Takamura, T. Fukasawa, H. Ogawa, Y. Ito, T. Ichiki, Y. Horiike
Study on elemental technologies for creation of healthcare chip fabricated on polyethylen trephthalate plate
IEICE Trans. Electron. E84-C, 1801-1806 (2001).

[34] A. Oki, Y. Takamura, Y. Ito, Y. Horiike
pH change of a buffer in a microcapillary chip and its suppression
Electrophoresis 23, 2860-2864 (2002).

[35] M. Ueda, T. Hayama, Y. Takamura, Y. Horiike, Y. Baba
Translocation of a long DNA chain passing through a nanofabricated pore
Bioimages 10, 9-18 (2002).

[36] M. Ueda, T. Hayama, Y. Takamura, Y. Horiike, Y. Baba
Investigation of the possibility of geometrical electrophoresis
Electrophoresis 23, 2635-2641 (2002).

[37] K. Kerman, Y. Morita, Y. Takamura, E. Tamiya
Label-free electrochemical detection of DNA hybridization on gold electrode
Electrochem. Comm. 5, 887-891 (2003).

[38] A. Oki, H. Ogawa, Y. Takamura, Y. Horiike
Biochip which examines hepatic function by employing colorimetric method
Jpn. J. Appl. Phys. [2] Lett. 42, L342-L345 (2003).

[39] A. Oki, M. Takai, H. Ogawa, Y. Takamura, T. Fukasawa, J. Kikuchi, Y. Ito, T. Ichiki, Y. Horiike
Healthcare Chip for Checking Health Condition from Analysis of Trace Blood Collected by Painless Needle
J. Appl. Phys. 42, 3722-3727 (2003).

[40] Y. Takamura, H. Onoda, H. Inokuchi, S. Adachi, A. Oki, Y. Horiike
Low-voltage electroosmosis pump for stand-alone microfluidcs devices
Electrophoresis 24, 185-192 (2003).

[41] M. Ueda, K. Taniguchi, Y. Takamura, Y. Horiike, Y. Baba
Fluorescence Emission Control of Long DNA Molecules Adsorbed on Micro electrode Surfaces by External Voltage
Jpn. J. Appl. Phys. [2] Lett. 42, L788-L790 (2003).

[42] N. Kaji, Y. Tezuka, Y. Takamura, M. Ueda, T. Nishimoto, H. Nakanishi, Y. Horiike, Y. Baba
Separation of Long DNA Molecules by Quartz Nanopillar Chips under a Direct Current Electric Field
Anal. Chem. 76, 15-22 (2004).

 
【特許リスト】
1) 特開2004 - 000217
 流路を用いたDNAのトラップ・リリース装置ならびにDNAのトラップ・リリース方法
2) 特開2003 - 274924
 細胞分離方法及び装置
3) 特開2003 - 066005
 細胞の電気泳動方法及び装置
4) 特開2002 - 277479
 液体の移動装置および血液分析装置とそれらの製造方法
5) 特開2002 - 257838
 位置決め可能な駆動機構とそれを有するチップ
6) 特開平10 - 197329
 液滴の振動計測方法及び装置
 

【国際学会プロシーディング】
1) Iiduka, Y. Morita, E. Tamiya, Y. Takamura, "Optical emission spectrometer of aqueous solution samples employing liquid electrode plasma", Micro Total Analysis Systems 2004, 1, pp 423-425, Cambridge. The Royal Society of Chemistry (2004) .
2) Y. Tomizawa, K. Yuhki, Y. Morita, E. Tamiya, Y. Takamura, "Quantitative analysis of molecular trap employing electric and hydro drag force field", Micro Total Analysis Systems 2004, 1, pp 659-661, Cambridge. The Royal Society of Chemistry (2004) .
3) K. Yuhki, Y. Tomizawa, Y. Morita, E. Tamiya, Y. Takamura, "Automated extraction and purification device of DNA from cells employing electric and hydro drag force field", Micro Total Analysis Systems 2004, 2, pp 294-296, Cambredge. The Royal Society of Chemistry (2004) .
4) K. Idegami, M. Kobayashi, Y. Takamura, E. Tamiya, "Development of a novel immunosensor based on microchip zone electrophoresis", Micro Total Analysis Systems 2004, 1, pp 70-71, Cambridge. The Royal Society of Chemistry (2004) .
5) S.R. Rao, S. Yamamura, Y. Takamura, E. Tamiya, "Multiplexed microfluidic devices for single-cell manipulation and analysis", Micro Total Analysis Systems 2004, 1, pp 61-63, Cambridge. The Royal Society of Chemistry (2004) .
6) S. Yamamura, S.R. Rao, M. Omori, Y. Tokimitsu, S. Kondo, H. Kishi, A. Muraguchi, Y. Takamura, E. Tamiya, "High-throughput screening and analysis for antigen specific single-cell using microarray", Micro Total Analysis Systems 2004, 1, pp 78-80, Cambridge. The Royal Society of Chemistry (2004) .
7) Y. Akagi, S.R. Rao, Y. Morita, Y. Takamura, E. Tamiya, "Screening of a novel neurotrophic factor using micro array cell-based chip and its response on PC12 cells neurosignaling pathway", Micro Total Analysis Systems 2004, 2, pp 309-311, Cambridge. The Royal Society of Chemistry (2004) .
8) M. Takai, H. Onoda, K. Ishihara, Y. Takamura, Y. Horiike, "Newly designed biocompatible polymers having phospholipid polar group for electro-osmosis pump actuated cell sorter chip", Micro Total Analysis Systems 2004, 2, pp 115-117, Cambridge. The Royal Society of Chemistry (2004) .
9) N. Kaji, Y. Tezuka, Y. Takamura, T. Nishimoto, H. Nakanishi, Y. Horiike, Y. Baba, "Effect of electroosmotic flow in nanopillar chips on DNA separation: experimental results and numerical simulations", Micro Total Analysis Systems 2004, 2, pp 210-212, Cambridge. The Royal Society of Chemistry (2004) .
 
※「1期生」 = 平成13年度採用研究者 2001年〜2004年
※「2期生」 = 平成14年度採用研究者 2002年〜2005年
※「3期生」 = 平成15年度採用研究者 2003年〜2006年
 
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