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[1] |
Fullerene-oligonucleotide conjugates: photo-induced sequence-specific DNA cleavage, Boutorine, A. S.; Tokuyama, H.; Takasugi M.; Isobe H.; Nakamura E.; Helene, C. Angew. Chem. Int. Ed. Engl. 1994, 33 (23/24), 2462-2465; Angew. Chem. 1994, 106 (23/24), 2526-2529.
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[2] |
Photoaddition of silyl ketene
acetal to [60]fullerene. Synthesis of α-fullerene-substituted
carboxylic esters, Tokuyama, H.; Isobe, H.; Nakamura,
E. J. Chem. Soc., Chem. Commun. 1994, (24), 2753-2754.
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[3] |
Methano- and propanofullerenes by [1 + 2] and [3 + 2] cycloadditions of vinylcarbene species, Tokuyama, H.; Isobe, H.; Nakamura, E. Bull. Chem. Soc. Jpn. 1995, 68 (3), 935-941.
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[4] |
Regio- and diastereo-controlled double cycloaddition to [60]fullerene: One-step synthesis of CS and C2 chiral organofullerenes with new tris-annulating reagents, Nakamura, E.; Isobe, H.; Tokuyama, H.; Sawamura, M. Chem. Commun. 1996, (15), 1747-1748.
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[5] |
Synthetic and computational studies on symmetry-defined double cycloaddition of a new tris-annulating reagent to C60, Isobe, H.; Tokuyama, H.; Sawamura, M.; Nakamura, E. J. Org. Chem. 1997, 62 (15), 5034-5041.
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[6] |
Optical resolution of chirally functionalized [60]fullerene through formation of diastereomeric methoxyphenylacetic acid esters, Isobe, H.; Sawamura, M.; Nakamura, E. Fullerene Sci. Technol. 1999, 7(4), 519-528.
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[7] |
Nonstatistical binding of a protein to clustered carbohydrates, Horan, N.; Yan, L.; Isobe, H.; Whitesides, G. M.; Kahne, D. Proc. Natl. Acad. Sci. USA 1999, 96 (21), 11782-11786.
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[8] |
A cage with fullerene end caps, Isobe, H.; Ohbayashi, A.; Sawamura, M.; Nakamura, E. J. Am. Chem. Soc. 2000, 122 (11), 2669-2670.
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[9] |
Pentaorgano[60]fullerene R5C60-. A water soluble hydrocarbon anion, Sawamura, M.; Nagahama, N.; Toganoh, M.; Hackler, U. E.; Isobe, H.; Nakamura, E.; Zhou, S. -Q.; Chu, B. Chem. Lett. 2000, (9), 1098-1099.
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[10] |
Functionalized fullerene as a new artificial vector for transfection, Nakamura, E.; Isobe, H.; Tomita, N.; Sawamura, M.; Jinno, S.; Okayama, H. Angew. Chem. Int. Ed. 2000, 39 (23), 4254-4257; Angew. Chem. 2000, 112 (23), 4424-4427.
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[11] |
Ternary complexes between DNA, polyamine and cucurbituril. A modular approach to DNA binding molecules, Isobe, H.; Tomita, N.; Lee, J. W.; Kim, H. -J.; Kim, K.; Nakamura, E. Angew. Chem. Int. Ed. 2000, 39 (23), 4257-4260; Angew. Chem. 2000, 112 (23), 4427-4430.
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[12] |
One-step multiple-addition of amine to [60]fullerene. Synthesis of tetra(amino)fullerene epoxide under photochemical aerobic conditions, Isobe, H.; Tomita, N.; Nakamura, E. Org. Lett. 2000, 2 (23), 3663-3665.
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[13] |
Spherical bilayer vesicles of fullerene based surfactants in water: A laser light scattering study, Zhou, S.; Burger, C.; Chu, B.; Sawamura, M.; Nagahama, N.; Toganoh, M.; Hackler, U. E.; Isobe, H.; Nakamura, E. Science 2001, 291 (5510), 1944-1947.
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[14] |
Atomic force microscope studies on condensation of plasmid DNA with functionalized fullerene, Isobe, H.; Sugiyama, S.; Fukui, K. -i.; Iwasawa, Y.; Nakamura, E. Angew. Chem. Int. Ed. 2001, 40 (18), 3364-3367; Angew. Chem. 2001, 113 (18), 3468-3471.
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[15] |
Synthesis and transfection capability of multi-functionalized fullerene polyamine, Isobe, H.; Tomita, N.; Jinno, S.; Okayama, H.; Nakamura, E. Chem. Lett. 2001, (12), 1214-1215.
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[16] |
Doping effects of tetra(amino)fullerene epoxide in conducting polymer thin film, Fujii, A.; Umeda, T.; Isobe, H.; Nakamura, E.; Yoshino, K. Jpn. J. Appl. Phys. 2001, 40, L1390-L1393.
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[17] |
Synthesis of disubstituted cucurbit[6]uril and its rotaxane derivative, Isobe, H.; Sato, S.; Nakamura, E. Org. Lett. 2002, 4(8), 1287-1289.
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[18] |
Doping effects of novel fullerene derivatives in conducting polymer, Shirakawa, T.; Umeda, T.; Nishihara, Y.; Fujii, A.; Isobe, H.; Nakamura E. Yoshino K. Synth. Met. 2003, 137 (1-3), 1415-1416.
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[19] |
Synthesis of fullerene glycoconjugates through sulfide connection in aqueous media, Isobe, H.; Mashima, H.; Yorimitsu, H.; Nakamura, E. Org. Lett. 2003, 5 (23), 4461-4464.
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[20] |
Multi-layer vesicles and vesicle clusters formed by fullerene-based
surfactant C60(CH3)5K, Burger, C.; Hao, J.; Ying, Q.; Isobe, H.;
Sawamura, M.; Nakamura, E.; Chu, B. J. Coll. Inter. Sci.2004, 275(2),
632-641.
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【総説】 |
1) |
Cyclopropenone acetals-Synthesis and reaction, Nakamura, M.; Isobe, H.; Nakamura, E. Chem. Rev. 2003, 103 (4), 1295-1326. |
2) |
Functionalized fullerenes in water. The first 10 years of their chemistry, biology, and nanoscience, Nakamura, E.; Isobe, H. Acc. Chem. Res. 2003, 36 (11), 807-815. |
3) |
Organofullerenes in water, Nakamura, E.; Isobe, H. Dekker Encyclopedia of Nanoscience and Nanotechnology, Dekker, New York, 2779 - 2789 (2004).
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【その他(解説、著書等)】 |
1) |
化学修飾と機能分子設計、中村栄一、澤村正也、磯部寛之、季刊化学総説「炭素第三の同素体 フラーレンの化学」、日本化学会編、学会出版センター、 Vol. 43, pp 165-171 (1999). |
2) |
鏡像異性体がみるみる増える!?不斉起源の謎にせまる、磯部寛之、中村栄一、化学、化学同人、 2000, 55 (7), 62-63. |
3) |
水溶性フラーレンの科学、磯部寛之、中村栄一、現代化学、東京化学同人、12月号、2001, 369, 59-65. |
4) |
遺伝子を運ぶフラーレン(天然物談話会奨励賞)、磯部寛之、化学、化学同人、 2001, 33-34. |
5) |
難病克服に"新兵器"、磯部寛之、中村栄一、日経サイエンス、日経新聞社、2002, (8), 38-41. |
6) |
フラーレン 難病克服の"新兵器"、磯部寛之、中村栄一、別冊日経サイエンス138「ここまで来たナノテク」、日経新聞社、(2003). |
7) |
フラーレンとDNA、磯部寛之、中村栄一、高分子2003, 52 (3), 142. |
8) |
有機フラーレンの形作る超分子構造-膜と液晶-、中村栄一、松尾豊、磯部寛之、澤村正也、未来材料2003, 3 (4), 6-12. |
9) |
水溶性フラーレンの合成とバイオ機能,磯部寛之,中村栄一,「超分子科学−ナノ材料創製に向けて」,化学同人,p379-386. |
10) |
水溶性フラーレンの可能性,磯部寛之,中村栄一,「水溶性高分子の新展開」,シーエムシー出版,p170-176 (2004). |
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【特許リスト】 |
1) |
Fullerene derivatives for potential use in gene therapy, Nakamura, E.; Sawamura, M.; Isobe, H. WO 99-JP1146 (PCT 国際特許 (1999)), JP98-58614 (Priority) |
2) |
アミノ化フラーレン誘導体、中村栄一、磯部寛之、特開2002-88075 |
3) |
フラーレン誘導体の重合体およびその製造方法、中村栄一、磯部寛之、特開2002-38486 |
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※「1期生」 = 平成13年度採用研究者 2001年〜2004年
※「2期生」 = 平成14年度採用研究者 2002年〜2005年
※「3期生」 = 平成15年度採用研究者 2003年〜2006年
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