Basic Technology to Establishing Tailor-Made Medicine by Utilizing Genome Information

Research Supervisor

Takehiko Sasazuki(President, International Medical Center of Japan)

Year Started



This research field aims at implementing drug discovery based on genome information and preventing and treating diseases according to individual body composition (tailor-made medical treatment). It focuses on techniques which provide the basis for revolutionary treatment and prevention methods related to challenges such as constructing new analysis systems for genome information and elucidating multifactorial disorders and undertaking drug discovery. In particular, emphasis is placed on research utilizing genome information for elucidating and developing drugs in relation to the receptivity and resistance towards highly heritable diseases or infectious diseases. Equal attention is given to investigating the genetic and environmental factors specific to our country for lifestyle diseases, to developing methods for their prevention based on genome information, and to developing techniques for rapidly and accurately clarifying individual differences with respect to drug sensitivity (effectiveness and adverse effects) based on genome information. New highly efficient techniques for processing genome information (SNPs) are also sought in order to provide the basis of the above research areas.

Year Started : 2004

Hiroyuki Aburatani
Professor, The University of Tokyo
Comprehensive Analysis of Chromosomal Copy Numbers and Allelic Gene Expression
Seishi Ogawa
Associate Professor, The University of Tokyo
Identification of Genetic Basis for Development of GVHD
Atsushi Maruyama
Professor, Kyushu University
Genotyping Method on the Basis of Molecular-chaperone Engineering
Masaki Mori
Professor, Kyushu University
Global Analysis of Factors Related to Carcinogenesis, Progression and Treatment Sensitivity of Colorectal Cancer

Year Started : 2003

Tadao Arinami
Professor, The University of Tsukuba
Collaborative Study to Identify Schizophrenia Susceptibility Genes
Ituro Inoue
Professor, Tokai University
Identification of Susceptibilities of Sub-common Disease and Development of Personalized Medicine
Norio Teramae
Professor, Tohoku University
Gene Diagnosis based on Self-assembled Bio-molecular Systems and Fluorescent Small Ligands
Fumihiko Matsuda
Professor, Kyoto University
Trans-ethnic Genomics Study of Multigenic Disorders by Japan/France International Collaboration

Year Started : 2002

Johji Inazawa
Professor, Tokyo Medical and Dental University
Establishment of High-resolution Microarray CGH and Exploring Cryptic Chromosome Alterations in Cancer and in Patients with Genetic Diseases
Norihiro Kato
Director, International Medical Center of Japan
Multi-phased Investigation of Genomic Epidemiology in Hypertension and its Associated Disorders
Jun Takeda
Professor, Gifu University
Molecular Dissection of the HNF-transcription Network and Identification of Genes Responsible for Type 2 Diabetes Mellitus
Tatsushi Toda
Professor, Osaka University
Identification of Genes and Drug Development for Parkinson's Disease based on Genome Analysis
Hiroyuki Mano
Professor, Jichi Medical School
Characterization Human Disorders with a High-throughput Analysis of the Regulatory Mechanism for Gene Expression


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