Translational Research for Intractable Immune Disorders and Infectious Diseases -Aiming at Creation of Novel Strategies Through Elucidation of Molecular Mechanisms of Pathogenesis-

Research Supervisor

Tadamitsu Kishimoto


Of advanced medical treatment including regenerative medicine and antibody engineering, the research area includes research of fundamentals and application of next-generation medical technologies, primarily advanced medical technologies for diseases dealing with immunity (for example incurable immunological diseases and infectious diseases) and including other related advanced medical technologies. In specific terms research includes elucidation of the onset incurable immunological diseases (autoimmune disease and allergies) on the genetic level and treatment based on it, such as antibody treatment methods or genetic treatment methods, development of DNA vaccines and stem cell medical treatment, and fundamental research that ties into development of new vaccines and medicines for tuberculosis, malaria, AIDS bacteria and protozoan, and viral infection.

Year Started : 2003

Hitoshi Kikutani
Professor, Osaka University
Roles of Semaphorin Molecules in the Immune System
Shimon Sakaguchi
Professor, Kyoto University
A Novel Strategy of Immunoregulation with Regulatory T Cells
Chihiro Sasakawa
Professor, The University of Tokyo
Studies of the Mechanisms of Mucosal Infection and Modulation of the Host Defense System by Pathogenic Bacteria, and its Application for Controlling Infectious Disease
Shinya Yamanaka
Professor, Kyoto University
Generation of Ideal Pluripotent Stem Cells for Clinical Application

Year Started : 2002

 Hiroshi Kiyono
Professor, The University of Tokyo
Immunobiology of M Cells for the Development of Mucosal Vaccine
Shigeo Koyasu
Professor, Keio University
Infectious Disease Control by Understanding the Strategy of Pathogenic Microbes Affecting Host Immune System
Nobuo Sakaguchi
Professor, Kumamoto University
New Strategy against Infectious and Immune Diseases by Developing Generation of High Affinity Antibodies
Yasuo Chinzei
Visiting Professor, Mie University
Molecular Mechanisms of Malarial Parasite Infection of the Host Liver and Development of Novel Antimalarial Strategies Preventing Malarial Transmission
Atsushi Miyajima
Professor, The University of Tokyo
Studies on Hematopoiesis and Immune Reactions in Liver

Year Started : 2001

Yoshihiro Kawaoka
Professor, The University of Tokyo
Understanding the Replication Cycle of Influenza Virus and its Application
Tsukasa Seya
Professor, Hokkaido University
Innate Immunity in Association with Human Incurable Diseases
Toshiyuki Takai
Professor, Tohoku University
Conquest of Immune Disorders by Analyzing Immunoglobulin-Like Receptor (IgLR) Functions
Kenji Nakanishi
Professor, Hyogo College of Medicine
Therapeutic Approach to Innate Type Atopy by Focusing on IL-18
Kensuke Miyake
Professor, The University of Tokyo
Molecular Mechanisms Underlying Recognition/Signaling of Endotoxin


Quick Access


  • ACT-I
  • ACT-X
  • ALCA
  • manual
  • AIP Network Lab
  • Global Activities
  • Diversity
  • SDGs
  • OSpolicy
  • Yuugu
  • Questions