Translational Research for Intractable Immune Disorders and Infectious Diseases -Aiming at Creation of Novel Strategies Through Elucidation of Molecular Mechanisms of Pathogenesis-

Research Supervisor

Tadamitsu Kishimoto

Outline

Of advanced medical treatment including regenerative medicine and antibody engineering, the research area includes research of fundamentals and application of next-generation medical technologies, primarily advanced medical technologies for diseases dealing with immunity (for example incurable immunological diseases and infectious diseases) and including other related advanced medical technologies. In specific terms research includes elucidation of the onset incurable immunological diseases (autoimmune disease and allergies) on the genetic level and treatment based on it, such as antibody treatment methods or genetic treatment methods, development of DNA vaccines and stem cell medical treatment, and fundamental research that ties into development of new vaccines and medicines for tuberculosis, malaria, AIDS bacteria and protozoan, and viral infection.

Year Started : 2003

Hitoshi Kikutani

Professor, Osaka University

Roles of Semaphorin Molecules in the Immune System

Shimon Sakaguchi

Professor, Kyoto University

A Novel Strategy of Immunoregulation with Regulatory T Cells

Chihiro Sasakawa

Professor, The University of Tokyo

Studies of the Mechanisms of Mucosal Infection and Modulation of the Host Defense System by Pathogenic Bacteria, and its Application for Controlling Infectious Disease

Shinya Yamanaka

Professor, Kyoto University

Generation of Ideal Pluripotent Stem Cells for Clinical Application

Year Started : 2002

Hiroshi Kiyono

Professor, The University of Tokyo

Immunobiology of M Cells for the Development of Mucosal Vaccine

Shigeo Koyasu

Professor, Keio University

Infectious Disease Control by Understanding the Strategy of Pathogenic Microbes Affecting Host Immune System

Nobuo Sakaguchi

Professor, Kumamoto University

New Strategy against Infectious and Immune Diseases by Developing Generation of High Affinity Antibodies

Yasuo Chinzei

Visiting Professor, Mie University

Molecular Mechanisms of Malarial Parasite Infection of the Host Liver and Development of Novel Antimalarial Strategies Preventing Malarial Transmission

Atsushi Miyajima

Professor, The University of Tokyo

Studies on Hematopoiesis and Immune Reactions in Liver