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- Fundamental Technologies for Medicine Concerning the Generation and Regulation of Induced Pluripotent Stem (iPS) Cells
Fundamental Technologies for Medicine Concerning the Generation and Regulation of Induced Pluripotent Stem (iPS) Cells
※ Affiliations and titles are as of the end of the research activity.
Research Supervisor
Toshio Suda（Professor, School of Medicine, Keio University ）
Overview
The objective of this research area is to establish fundamental technologies contributing to advanced medicine through the development of cellular reprogramming technology. Remarkable progress has been made in this field recently, especially the generation of iPS cells. The research objectives include the advancement and simplification of this technology, the elucidation of pathological mechanisms through the development of model cells, the formulation of new therapy strategies, and novel methods for the early discovery of diseases.
Specifically, included is research on cellular reprogramming and differentiation mechanisms using genomics, chromosome structure and epigenetic analysis; research on gene transfer regulation; high-throughput screening of reprogramming-inducing compounds; and research using iPS cells generated from patients with congenital diseases for the elucidation of pathological mechanisms. Moreover, the research also covers an area that may lead to the pioneering of new therapy methods and preventive medicine through the integration of stem cell research and pathological studies.
Specifically, included is research on cellular reprogramming and differentiation mechanisms using genomics, chromosome structure and epigenetic analysis; research on gene transfer regulation; high-throughput screening of reprogramming-inducing compounds; and research using iPS cells generated from patients with congenital diseases for the elucidation of pathological mechanisms. Moreover, the research also covers an area that may lead to the pioneering of new therapy methods and preventive medicine through the integration of stem cell research and pathological studies.
Research Area Advisors
| Hiroyuki Sasaki |
| Mikiko Siomi |
| Yoshimi Takai |
| Masatoshi Takeichi |
| Toru Nakano |
| Yoshihide Hayashizaki |
| Kohei Miyazono |
Year Started: 2008
Research Director
Shunsuke Ishii (RIKEN)
Research Director
Atsushi Iwama (Professor, Chiba University)
- Koji Eto (Professor, Center for iPS Cell Research and Application, Kyoto University)
- Mitsuhiro Endoh (RIKEN)
- Hiroaki Honda (Professor, Research Institute for Radiation Biology and Medicine, Hiroshima University)
Research Director
Akihiko Okuda (Professor, Saitama Medical University)
- Yasushi Okazaki (Team Leader, Center for Integrative Medical Sciences, Riken)
- Satoru Takahashi (Professor, University of Tsukuba)
Research Director
Mitsuo Oshimura (Professor, Tottori University)
- Shoichiro Sumi (Institute for Frontier Medical Sciences, Kyoto University)
Research Director
Haruhiko Koseki (RIKEN)
Research Director
Hideyuki Saya (Professor, Faculty of Medicine, Keio University)
- Koichi Akashi (Professor, Graduate School of Medical Sciences, Kyushu University)
- Kouichi Akahane (DAIICHI SANKYO COMPANY, LIMITED)
- Tohru Takashi (DAIICHI SANKYO COMPANY, LIMITED)
- Nobuhide Doi
- Atsushi Hirao (Professor, Cancer Research Institute, Kanazawa University)
- Hiroshi Yanagawa (Professor)
Research Director
Takashi Shinohara (Professor, Graduate School of Medicine, Kyoto University)
Research Director
Satoru Senju (Kumamoto University)
- Yasushi Uemura
Research Director
Hitoshi Niwa (Center for Developmental Biology, RIKEN)
- Tomoharu Osada
- Shinji Masui (Center for iPS Cell Research and Application, Kyoto University)
Research Director
Yoshihiro Yoneda (Director General, The Research Foundation for Microbial Diseases of Osaka University)
- Masahiro Oka (Graduate School of Frontier Biosciences, Osaka University)
- Hiroshi Masumoto (Professor, Department of Frontier Research and Development, Kazusa DNA Research Institute)
Year Started: 2009
Research Director
Haruhisa Inoue (Professor, Center for iPS Cell Research and Application, Kyoto University)
- Nobuhisa Iwata (Professor, Nagasaki University)
- Tetsuya Suhara
- Tatsushi Toda (Professor, Osaka University)
Research Director
Takumi Era (Professor, Kumamoto University)
- Mitsuyoshi Nakao (Professor, Kumamoto University)
- Ryuichi Nishinakamura (Professor, Kumamoto University)
Research Director
Mitinori Saitou (Professor, Graduate School of Medicine, Kyoto University)
- Kurimoto Kazuki (Center for Developmental Biology, RIKEN)
Research Director
Nobuyuki Takakura (Professor, Research Institute for Microbial Diseases, Osaka University)
Research Director
Yoshiko Takahashi (Professor, Graduate School of Science, Kyoto University)
- Kazuo Emoto (Professor, School of Science, The University of Tokyo)
- Hajime Ogino (Professor, Nagahama Institute of Bio-Science and Technology)
- Takahiro Kunisada (Professor, Graduate School of Medicine, Gifu University)
Research Director
Noriyuki Tsumaki (Osaka University)
- Hideki Yoshikawa (Professor, Osaka University)
Research Director
Eisuke Nishida (Professor, Graduate School of BIOSTUDIES, Kyoto University)
Year Started: 2010
Research Director
Masaki Ieda (Faculty of Medicine, Keio University)
Research Director
Mineo Kurokawa (Professor, The University of Tokyo)
Research Director
Yutaka Hanazono (Professor, Jichi Medical University)
- Hiroshi Nagashima (Professor, School of Agriculture, Meiji University)
Research Director
Atsushi Miyajima (Professor, The University of Tokyo)
- Takahiro Ochiya
- Yasuyuki Sakai (Professor, The University of Tokyo)
Research Director
Ken-Ichi Yamamura (Professor, Kumamoto University)
- Satoko Arai (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)
- Toru Miyazaki (The University of Tokyo)
Research Director
Minoru Yoshida (RIKEN)
- Yu-Ichi Goto
