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- Creation of a Novel Technology towards Diagnosis and Treatment Based on Understanding of Molecular Pathogenesis of Psychiatric and Neurological Disorders
Creation of a Novel Technology towards Diagnosis and Treatment Based on Understanding of Molecular Pathogenesis of Psychiatric and Neurological Disorders
※ Affiliations and titles are as of the end of the research activity.
Research Supervisor
Teruhiko Higuchi（President, National Center of Neurology and Psychiatry）
Overview
Psychiatric and neurological disorders attributable to disorders of higher brain functions, such as cognition and emotion, are an issue of high social demand in Japan, which is increasingly affected by a declining birthrate, aging, and social tension. This Research Area aims at the creation of a novel technology for prevention, diagnosis, and therapy for psychiatric and neurological disorders.
More specifically, it targets research towards evidence-based objective diagnosis and curative therapy based on the understanding of molecular pathogenesis of psychiatric and neurological disorders that engender higher brain function disorders. Exemplary research objects include: development of diagnostic methods using, for example, biological markers, which are available as an objective index from biochemical or molecular genetic points of view, or functional markers such as non invasive brain imaging technology; analysis of animals used in disease modeling reproducing gene mutation or environmental change; and search for and identification of target molecules towards innovative drug development for implementing basic treatment.
This Research Area also deems important those studies that aim at organic fusion of different research areas or study methods, including clinical study for disorders vs. fundamental study like brain science, psychiatric disorder study vs. neurological disorder study, and intermediate phenotype analysis studies like brain imaging vs. gene analysis study, to advance these studies.
More specifically, it targets research towards evidence-based objective diagnosis and curative therapy based on the understanding of molecular pathogenesis of psychiatric and neurological disorders that engender higher brain function disorders. Exemplary research objects include: development of diagnostic methods using, for example, biological markers, which are available as an objective index from biochemical or molecular genetic points of view, or functional markers such as non invasive brain imaging technology; analysis of animals used in disease modeling reproducing gene mutation or environmental change; and search for and identification of target molecules towards innovative drug development for implementing basic treatment.
This Research Area also deems important those studies that aim at organic fusion of different research areas or study methods, including clinical study for disorders vs. fundamental study like brain science, psychiatric disorder study vs. neurological disorder study, and intermediate phenotype analysis studies like brain imaging vs. gene analysis study, to advance these studies.
Research Area Advisors
| Tadao Arinami |
| Hironobu Ichikawa |
| Yasuto Itoyama |
| Yuuji Okazaki |
| Yasushi Kajii |
| Ushio Kikkawa |
| Takaaki Kirino |
| Katsuhiko Mikoshiba |
| Yoshiharu Yonekura |
Year Started: 2007
Research Director
Kaoru Inokuchi (Professor, Graduate School, University of Toyama)
- Satoshi Kida (Professor, Tokyo University Of Agriculture)
- Yoshiharu Kim
- J. Yutaka
- Shigeru Morinobu (Hiroshima University)
Research Director
Takeshi Iwatsubo (Professor, The University of Tokyo)
- Hiroyuki Arai (Professor, Tohoku University)
Research Director
Kozo Kaibuchi (Professor, Nagoya University)
- Nakao Iwata (Professor, Faculty of Medicine, Fujita Health University)
- Yasuhiro Kawasaki (University of Toyama)
- Tsutomu Takahashi (University of Toyama)
- Hashimoto Ryota (Osaka University)
Research Director
Ryosuke Takahashi (Professor, Graduate School of Medicine, Kyoto University)
- Satoshi Ogawa (Professor, Kanazawa University)
- Makoto Kinoshita (Graduate School of Medicine, Kyoto University)
- Shunichi Takeda (Professor, Graduate School of Medicine, Kyoto University)
- Nobutaka Hattori (Professor, Faculty of Medicine, Juntendo University)
- Osamu Hori (Professor, Kanazawa University)
- Kazutoshi Mori (Professor, Graduate School of Science, Kyoto University)
Research Director
Miyakawa Tsuyoshi (Professor, Fujita Health University)
- Kazuhiro Ikenaka (Professor)
- Hiroshi Ichinose (Professor, Tokyo Institute of Technology)
- Yukiyasu Kamitani (Department Head, Computational neuroscience laboratories, Advanced Telecommunications Research Institute International)
- Katsunori Kobayashi (Nippon Medical School)
- Takahashi Takuya (Professor, Graduate School of Medicine, Yokohama City University)
- Akinori Nishi (Professor, School of Medicine, Kurume University)
- Shigeki Yuasa
Year Started: 2008
Research Director
Hiroshi Onodera
- Toshio Imai
- Seokbeom Kim (Graduate School of Natural Science and Technology, Okayama University)
- Masahiro Kohzuki (Professor, Tohoku University)
- Atsushi Nakahira (Professor, Osaka Prefecture University)
- Masaya Nakamura
Research Director
Nobumasa Kato (Professor, Faculty of Medicine, Showa University)
- Haruhiro Higashida (Research Center for Child Mental Development, Kanazawa University)
- Hidenori Yamasue (The University of Tokyo)
Research Director
Masami Kojima
- Yasumasa Okamoto (Hiroshima University)
- Hiroshi Kunugi
- Keizo Takao
- Masami Takahashi (Professor, Kitasato University)
- Teiichi Furuichi (Professor, Faculty of Science and Engineering, Tokyo University of Science)
- J. Yutaka
- Shigeto Yamawaki (Professor, Hiroshima University)
Research Director
Gen Sobue (Professor, Nagoya University)
- Shin Kwak (The University of Tokyo)
- Koji Yamanaka (Professor, Nagoya University)
Year Started: 2009
Research Director
Yasuo Ihara (Professor, Doshisha University)
- Hiroshi Mori (Professor, Osaka City University)
- Tooru Sasaki
Research Director
Toru Takumi (Professor, Hiroshima University)
- Hidenori Suzuki (Professor, Nippon Medical School)
- Yoshiharu Yamamoto (Professor, The University of Tokyo)
Research Director
Toru Nishikawa (Professor, Tokyo Medical and Dental University)
- Kunimasa Arima
- Tetsuro Omori (Professor, Tokushima University)
- Koichi Tanaka (Professor, Tokyo Medical and Dental University)
- Kiyoshi Fukui (Professor, Tokushima University)
- Mitsutoshi Okazaki
Research Director
Nobuyuki Nukina (RIKEN)
- Hitoshi Okazawa (Professor, Tokyo Medical and Dental University)
- Masahisa Katsuno (Nagoya University)
- Nagai Yoshitaka
Research Director
Hidehiro Mizusawa (Professor, Tokyo Medical and Dental University)
- Hiroshi Tanaka (Professor, Tokyo Medical and Dental University)
- Masatoshi Hagiwara (Professor, Graduate School of Medicine, Kyoto University)
