[Innovative Measurement and Analysis] Year Started : 2023

Yasuyuki Ozeki

Innovative biological analysis using high-speed Raman microscopy, probes, and machine learning

Research Director
Yasuyuki Ozeki

Professor
Research Center for Advanced Science and Technology
The University of Tokyo

Collaborator
Mako Kamiya Professor
Department of Life Science and Technology
Tokyo Institute of Technology
Akira Funahashi Professor
Faculty of Science and Technology
Keio University
Outline

Living organisms are intricately woven from a myriad of diverse cells. Within these cells, an array of organelles and biomolecules engages in sophisticated interactions, underpinning the vital processes that sustain life. To elucidate these complex and dynamic cellular mechanisms, our research unites experts from the fields of high speed Raman microscopy (physics), Raman probes (chemistry), and advanced biological image analysis (information technology). Together, we endeavor to visualize, with unprecedented spatial precision, the myriad organelles and biomolecules active within living cells. Our ultimate aim is to establish methodologies that provide clarity to their multifaceted interactions, furthering our understanding of the fundamental mechanisms of life.

Takuya Kubo

Barrier breakthrough and social implementation on liquid phase separation by the fusion of molecularly and informative technology

Research Director
Takuya Kubo

Professor
Faculty of Science and Technology
Kyoto Prefectural University

Collaborator
Hikaru Takaya Professor
Faculty Life & Environmental Sciences
Teikyo University of Science
Ryo Yoshida Professor
The Institute of Statistical Mathematics
Inter-University Research Institute Corporation Research Organization of Information and Systems
Outline

In this study, we develop the innovative separation media for identifying single atom (groups) and a comprehensive data base in liquid phase separation due to an organic fusion of material design, chemical theory, and physical/chemical informatics. We challenge the precise separation of the compounds, which are not able to be separated by the presenting methods, such as isotope isomers and polymers of tiny differences. We also impellent a promotion for development of a data driven software to predict the retention in liquid phase separation.

Tamiki Komatsuzaki

Accelerated screening measurement platform utilizing individual differences among animals with intelligent online measurements

Research Director
Tamiki Komatsuzaki

Professor
Research Institute for Electronic Science
Hokkaido University

Collaborator
Keisuke Goda Professor
Graduate School of Science
The University of Tokyo
Masahiro Sonoshita Professor
Institute for Genetic Medicine
Hokkaido University
Outline

We develop an intelligent online measurement based screening platform that relies on the information of distributions of cancer degree (including mean, variance, and skewness) of individuals by integrating a flow optical imaging device with a multi objective multi armed bandit approach. This enables rapid screening with guaranteeing accuracy of measurements. We adopt the wing disc of fruit fly larvae, which is a pancreatic cancer model, as a phenotypic marker to differentiate from normal larvae, and quantify the degree of cure using a deep learning architecture, paving the way for rapid drug screening beyond conventional techniques relying on average efficacy of drugs.

Yuichi Taniguchi

Development of higher order molecular genome structure analysis technology based on physics and information theory

Research Director
Yuichi Taniguchi

Professor
Institute for Advanced Study
Kyoto University

Collaborator
Yasuaki Hiraoka Professor
Institute for Advanced Study
Kyoto University
Outline

Aiming at realizing 3D genome structure analysis at the molecular resolution, we develop sequencing based experimental methods for capturing proximity among nucleosome loci across the genome for various organisms and combine physics simulations and informatic theories for molecular level modeling. Furthermore, based on accumulated data on 3D genome structures and epigenome features, we develop an AI platform that predicts gene expressions from the 3D physical and chemical model of the genome.

Wataru Yashiro

Development of 4D+ X ray tomography for observing dynamics inside real materials

Research Director
Wataru Yashiro

Professor
International Center for Synchrotron Radiation Innovation Smart
Tohoku University

Collaborator
Kei Kamada Associate Professor
New Industry Creation Hatchery Center
Tohoku University
Hiroyuki Kudo Professor
Institute of Systems and Information Engineering
University of Tsukuba
Hitoshi Soyama Professor
Graduate School of Engineering
Tohoku University
Outline

In non repeating and non equilibrium systems, there are vast 4D unexplored regions that are inaccessible even by mankind’s most advanced measurement technology. In this study, the principal investigator (PI) and collaborating researchers (Co. PI) will further develop submillisecond and even 1 to 10 microsecond temporal resolution multimodal (e.g., element identification) 4D X ray CT by further developing the world’s first X ray CT with millisecond order temporal resolution, aiming to create a new academic field and eventually to solve various social problems.

Yutaka Yoshida

Measurement Data Driven Optimization System for Thin Film Process

Research Director
Yutaka Yoshida

Professor
Graduate School of Engineering
Nagoya University

Collaborator
Yusuke Ichino Professor
Engineering
Aichi Institute of Technology
Ataru Ichinose Grid Innovation Research Laboratory
Central Research Institute of Electrical Power Industry
Keiichi Horio Professor
Graduate School of Life Science and Systems Engineering
Kyushu Institute of Technology
Outline

The measurement data driven optimization system for thin film process will be developed for heteroepitaxial thin films of strongly correlated electron materials on single crystalline substrates. Advanced multi parameter measurement, Monte Carlo simulation, and Bayesian optimization will be performed to accelerate the optimization of the thin film fabrication process. The potential applications to multilayer films, nanocomposite thin films, and practical energy materials will also be demonstrated.

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