To elucidate the mechanism of necrosis (cell death) on the molecular level

The purpose of this JST project is to elucidate the mechanism of necrosis (cell death) on the molecular level. In the case of brain infarction, necrosis occurs by oxidative stress caused by a resumption of blood stream containing oxygen, followed by a short-term cessation of the blood stream in which a brain blood vessel is blocked.

Challenging this theme from the point of chemical biology, which clarifies life phenomena by a chemical point of view, chief scientist Sodeoka has developed new compounds, for example, "IM-54" that can inhibit necrosis exclusively. In this project, three groups working together mutually, are carrying out research towards the development of a completely new medical treatment of brain infarction or myocardial infarction. The first group is the "cell death control group", which aims at developing novel molecules and clarifying the mechanism of their behaviors based on "cell death control molecules", the second is the "live cell reaction group", which aims to develop identification methods of intracellular targets for molecules, and the third is the "live cell analysis group", which aims to develop new imaging techniques for live cells.


The final result briefing session of JST-ERATO Sodeoka Live Cell Chemistry Project will be held at Ito Hall of Tokyo University on Jan. 15, 2014.
   The date and time: Jan. 15, 2014, 13:00~18:00
   Place: Ito International Research Center, Tokyo University(7-3-1, Hongo, Bunkyo, Tokyo)
   The rate: Free of charge
   The language: Japanese

RIKEN Symposium “8th Frontier of Organic Synthetic Chemistry” was held at RIKEN WAKO, Chemical Biology Building, Suzuki Umetaro Hall on July 5, 2013. At this symposium, the lecture of seven affairs including organic synthetic chemistry, biology and chemical biology was performed, and it had active discussions by the speakers and the audiences.

Public opening of RIKEN is carried out every year. The ERATO Sodeoka Live Cell Chemistry Project participated in an exhibition alongside the demonstration, "Let's study organic compounds ~Mystery in form of molecules~" carried out by the Sodeoka Synthetic Organic Chemistry Laboratory. Panels of the ERATO project were presented, showing work on the cell death repressor and on Bio-Raman spectroscopy. Researchers explained the details of research to the visitors. Although the number of guests decreased in the afternoon due to the rainy weather, the visitors listened attentively to the explanations by the researchers.

   Site: Material and Science Research Building 6F; Time: 9:30~16:30
   Number of visitors: RIKEN 8046 (ERATO related ~100)
Public opening of RIKEN