19 August, 2014
The result of the Shibuya team
"Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration" was released.

30 July, 2014
The result of the Kinashi team
"Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking" was released.

29 July, 2014
The result of the Kurosaki team
"Memory B cells contribute to rapid Bc16 expression by memory follicular helper T cells" was published in PNAS.

2 July, 2014
"The third Symposium on this research area is going to be held on 8 October, 2014 " We are looking forward to your participation.

9 June, 2014
The result of the Fukui team
"DOCK5 functions as a key signaling adaptor that links FcgRI signals to microtubele dynamics during mast cell degranulation " was released.

6 June, 2014
The result of the Nagata team
"Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure" was released.

3 June, 2014
The result of the Arase team
"Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRa" was released.

3 June, 2014
The result of the Takeda team
"Generation of colonic IgA-secreting cells in the caecal patch" was released.

25 February, 2014
The result of the Arase team
"New autoimmune pathogenesis overturning prevailing orthodoxy" was released.

16 January, 2014
The result of the Shibuya team
"Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2" was released.

4 December, 2013
The result of the Taniguchi team
"Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection" was published in PNAS.

26 November, 2013
The result of the Takeda team
"Increased Th17-Inducing Activity of CD14+ CD163low Myeloid Cells in Intestinal Lamina Propria of Patients with Crohn’s Disease" was published in Gastroenterology.

30 October, 2013
The result of the Karasuyama team
"The skin is an important bulwark of acquired immunity against intestinal helminths" was published in Journal of Experimental Medicine.

13 September, 2013
The result of the Ohteki team
"Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses" was published in Immunity.

12 July, 2013
The result of the Nagata team
"Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells" was published in Science.

12 July, 2013
The result of the Kurosaki team
"Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation" was released.

26 April, 2013
The result of the Ohteki team
"A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential" was released.

22 February, 2013
The result of the Karasuyama team
"Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4" was released.

21 February, 2013
The result of the Hirano team
"Disease-Association Analysis of an Inflammation-Related Feedback Loop." was published in Cell Reports.

14 February, 2013
JST-CREST International Symposium
"Frontiers in Immunology and Inflammation" was held successfully at Hitotsubashi Memorial Hall, Tokyo. and immune homeostasis." Thank you very much to all who attended and contributed to the success of the symposium!

21 January, 2013
The result of the Yoshimura team
"Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis." was released.

5 December, 2012
The website of JST-CREST International Symposium "Frontiers in Immunology and Inflammation"
was renewed.
We are looking forward to your registration! (Deadline : January 31, 2013)

4 December, 2012
The result of the Taniguchi team
"Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction" was published in Proceedings of the National Academy of Sciences.

12 November, 2012
The result of the Arase team
"Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation." was released.

4 October, 2012
The result of the Kinashi team
"Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus" was published in Nature Communications.

24 August, 2012
Symposium; Deadline for
"Poster Abstracts Submission" and "Travel Fellowship " has been extended to Sep 18th 2012!
We are looking forward to your abstract submission!

23 July, 2012
The result of the Shibuya team
"Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor." was released.

21 May, 2012
The result of the Taniguchi team
"Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses" was released.

20 April, 2012
The result of the Fukui team
"Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2" was released.

30 March, 2012
The result of the Yoshimura team
"PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORg" was released.

7 March, 2012
The result of the Takeda team
"Intestinal CX3C chemokine receptor 1high (CX3CR31high) myeloid cells prevent T-cell-dependent colitis" was released.

20 Feburuary, 2012
The research areas of CREST "Immune system", CREST "Chronic Inflammation" and PRESTO "Chronic Inflammation" will hold the Joint International Symposium on 12th-13th February, 2013 in Tokyo, Japan.
We are now accepting registrations for participation and abstracts for poster presentations.

3 Feburuary, 2012
The result of the Hirano team
"Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier" was released.
6 September, 2011
The result of the Yoshimura team
"SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFNγ and IL-17A production" was published in The Journal of Experimental Medicine.
4 July, 2011
The result of the Shibuya team
"An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes" was published in The Journal of Experimental Medicine.
28 June, 2011
The result of the Taniguchi team
"Suppression of immune responses by nonimmunogenic oligonucleotides with high-affinity for HMGB proteins" was released.
27 June, 2011
The result of the Kurosaki team
"CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway" was released.
20 May, 2011
The result of the Yoshimura team
"Transcription factor Smad-independent T helper 17 cell induction by Transforming-Growth factor-b is mediated by suppression of Eomesodermin" was released.
28 April, 2011
The result of the Kurosaki team
"The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production" was published in Immunity.
19 April, 2011
The result of the Kurosaki team
"ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation" was released.
5 April, 2011
The result of the Yoshimura team
"The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells" was published in Nature Communications.
18 February, 2011
The result of the Oteki team
"Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction" was released.
9 February, 2011
The result of the Yoshimura team,
"Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance" was released.
7 February, 2011
The result of the Okazaki team,
"PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice" was released.
31 December, 2010
The result of the Kinashi team,
"Deficiency of Rap1-binding protein RAPL caused lymphoproliferative disorders through the mislocalization of p27kip1" was released.
30 November, 2010
Research Themes and Principle Investigators for 2010 were uploaded.
25 November, 2010
The result of the Nagata team,
"Calcium-dependent phospholipid scrambling by TMEM16F" was published in Nature.
27 October, 2010
"First Symposium of CREST "Immune System" Area" was held.
25 August, 2010
Selection of the new CREST projects for the FY2010 was announced.
2 projects were selected from this research area.
27 July, 2010
The result of the Karasuyama team,
"Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks" was released. JSTNews 2010 9 Science News Flash Video Windows Media Player