竹下 浩平（タケシタ　コウヘイ）

竹下 浩平
学位
薬学博士
所属・職位
大阪大学蛋白質研究所（未来戦略機構）
招へい研究員（特任助教）
URL
http://www.protein.osaka-u.ac.jp/rcsfp/supracryst/
研究分野
構造生物学

原著論文

  1. Takeshita K, Sakata S, Yamashita E, Fujiwara Y, Kawanabe A, Kurokawa T, Okochi Y, Matsuda M, Narita H, Okamura Y, Nakagawa A. X-ray crystal structure of voltage-gated proton channel. Nature Struct. Mol. Biol., 21(4):352-357 (2014)
  2. Berkyurek AC, Suetake I, Arita K, Takeshita K, Nakagawa A, Shirakawa M, and Tajima S. The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA. J. Biol. Chem., 289(1):379-386 (2014)
  3. Fujiwara Y, Takeshita K, Nakagawa A, Okamura Y. Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel. J. Biol. Chem., 288(25):17968 -17975 (2013)
  4. Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson HP, Okamura Y. Gating of the Designed Trimeric/Tetrameric Voltage-Gated H+ Channel. J. Physiol., つm591(Pt 3):627-640 (2012)
  5. Takeshita K, Tezuka T, Isozaki Y, Yamashita E, Suzuki M, Kim M, Yamanashi Y, Yamamoto T, Nakagawa A. Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J. Biochem., 152, 487-495 (2012)
  6. Fujiwara Y, Kurokawa T, Takeshita K, Kobayashi M, Okochi Y, Nakagawa A, Okamura Y. The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1. Nature Commun., 3, 816 (2012)
  7. Takeshita K, Suetake I, Yamashita E, Suga M, Narita H, Nakagawa A, and Tajima S. Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc. Natl. Acad. Sci. USA, 108, 9055-9059 (2011)
  8. Matsuda M, Takeshita K, Kurokawa T, Sakata S, Suzuki M, Yamashita E, Okamura Y, and Nakagawa A. Crystal structure of the cytoplasmic phosphatase and tensin homolog (PTEN)-like region of Ciona intestinalis voltage-sensing phosphatase provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity J. Biol. Chem., 286, 23368-23377 (2011)
  9. Mukai M, Ikegami K, Sugiura Y, Takeshita K, Nakagawa A, Setou M. Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway. Biochemistr y, 48:1084-1093 (2009)
  10. Goto T, Abe Y, Kakuta Y, Takeshita K, Imoto T & Ueda T, Crystal structure of tapes japonica lysozyme with substrate analogue - Structural basis of the catalytic mechanism and manifestation of its chitinase activity accompanied by quaternary structural change. Journal of Biological Chemistry, 282, 27459-27467. (2007)
  11. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. Febs Letters, 581, 4260-4264. (2007)
  12. Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara H, Fujimoto K, Izuhara K. Characterization of novel squamous cell carcinoma antigen-related molecules in mice. Biochemical and Biophysical Research Communications, 324, 1340-1345. (2004)
  13. Takeshita K, Hashimoto Y, Ueda T, Imoto T, A small chimerically bifunctional monomeric protein: Tapes japonica lysozyme. Cell. and Mol. Life Scie., 60, 1944-1951. (2003)
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総説等

  1. 竹下浩平, 岡村康司, 中川敦史「電位依存性プロトンチャネル（VSOP）の結晶構造から考察するプロトン漏洩制御機構」Journal of Japanese Biochemical Society 87(5): 625-628 (2015) doi:10.14952/SEIKAGAKU.2015.870625
  2. 竹下浩平, 岡村康司, 中川敦史,. Crystal Structure of voltage gated proton channel. SPring-8 Research Frontiere 2015
  3. 竹下浩平, 岡村康司, 中川敦史, 「電位依存性プロトンチャネルの結晶構造」ライフサイエンス新着論文レビュー (2014年３月27日)
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