Exploratory research on the molecular mechanism of cardiovascular homeostasis through myocardial-endothelial signaling
Yoshikazu Nakaoka
| Research Site | National Cerebral and Cardiovascular Center |
|---|---|
| Research Institute | |
| Director |
Content
The interaction between endothelium and myocardium mediated by humoral factors has important roles in cardiovascular homeostasis and development. We recently found that the interaction between endothelium and myocardium through angiopoietin-1 plays a critical role in the coronary vessel formation. The present study aims to reveal the physiological and pathological role of myocardium-derived angiopoietin-1 in the coronary angiogenesis and pulmonary arterial hypertension. The findings obtained from the present study will help us develop novel therapeutic strategies for the related cardiovascular diseases.
Publication
- Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, Nakaoka Y.* Interleukin-6/interleukin-21-signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015 May 19; 112(20): E2677-86. doi: 10.1073/pnas.1424774112. Epub 2015 May 4. (*corresponding author)
- Arita Y, Nakaoka Y*, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Hashimoto-Kataoka T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nature Communications 2014 Jul 29; 5: 4552. doi: 10.1038/ncomms5552. (*corresponding author)
