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Elucidating the mechanisms of disruption of homeostasis regulated by nutrition

Masato Iwabu (photo)

Masato Iwabu

Research Site The University of Tokyo
The University of Tokyo Hospital
Project Associate Professor

Content

In this era of hypernutrition, humans are seen to suffer from a shortening of lifespan due to associated lifestyle-related/cardiovascular diseases and malignancies. Failure to maintain a balanced diet is likely to disturb the mechanisms of homeostasis and prolong the stress response in the body, leading to the intercellular and inter-organ interactions being eventually disrupted. In the proposed research, therefore, I focus attention on adiponectin and its receptors in an attempt to elucidate the mechanisms of disruption of homeostasis as a compensatory mechanism as well as the molecular mechanisms of onset of associated diseases, thus contributing to advances in preemptive medicine.

Publication

  1. Okada-Iwabu M*, Yamauchi T*, Iwabu M*, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S and Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503, 493-498, 2013 (*These authors contributed equally to this work.)
  2. Kadowaki T, Yamauchi T, Okada-Iwabu M and Iwabu M. Adiponectin and its receptors: Implications for reduction of obesity-associated diseases and prolongation of longevity. The Lancet Diabetes and Endocrinology 2, 8-9, 2014
  3. Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T. Adiponectin/adiponectin receptor in disease and aging. npj Aging and Mechanisms of Disease 1, 15013, 2015
  4. Tanabe H, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hosaka T, Hato M, Fujii Y, Nakamura Y, Ogasawara S, Hino T, Murata T, Iwata S, Okada-Iwabu M, Iwabu M, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T and Yokoyama S. Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2. J Struct Funct Genomics. 16, 11-23, 2015
  5. Tanabe H, Fujii Y, Okada-Iwabu M*, Iwabu M*, Nakamura Y*, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T and Yokoyama S. Crystal structures of the human adiponectin receptors. Nature 520, 312-316, 2015 (*These authors contributed equally to this work.)