Elucidating the mechanisms of disruption of homeostasis regulated by nutrition
Masato Iwabu
Research Site |
The University of Tokyo |
The University of Tokyo Hospital |
Project Associate Professor |
Content
In this era of hypernutrition, humans are seen to suffer from a shortening of lifespan due to associated lifestyle-related/cardiovascular diseases and malignancies. Failure to maintain a balanced diet is likely to disturb the mechanisms of homeostasis and prolong the stress response in the body, leading to the intercellular and inter-organ interactions being eventually disrupted. In the proposed research, therefore, I focus attention on adiponectin and its receptors in an attempt to elucidate the mechanisms of disruption of homeostasis as a compensatory mechanism as well as the molecular mechanisms of onset of associated diseases, thus contributing to advances in preemptive medicine.
Publication
- Okada-Iwabu M*, Yamauchi T*, Iwabu M*, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S and Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503, 493-498, 2013 (*These authors contributed equally to this work.)
- Kadowaki T, Yamauchi T, Okada-Iwabu M and Iwabu M. Adiponectin and its receptors: Implications for reduction of obesity-associated diseases and prolongation of longevity. The Lancet Diabetes and Endocrinology 2, 8-9, 2014
- Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T. Adiponectin/adiponectin receptor in disease and aging. npj Aging and Mechanisms of Disease 1, 15013, 2015
- Tanabe H, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hosaka T, Hato M, Fujii Y, Nakamura Y, Ogasawara S, Hino T, Murata T, Iwata S, Okada-Iwabu M, Iwabu M, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T and Yokoyama S. Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2. J Struct Funct Genomics. 16, 11-23, 2015
- Tanabe H, Fujii Y, Okada-Iwabu M*, Iwabu M*, Nakamura Y*, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T and Yokoyama S. Crystal structures of the human adiponectin receptors. Nature 520, 312-316, 2015 (*These authors contributed equally to this work.)