Professor Dr. Yasuhisa Asano, Research Director of Asano Active Enzyme Molecule Project, and his collaborators, Dr. Kazuyuki Yasukawa and Dr. Shogo Nakano, engineered a new enzyme "(R )-stereoselective amine oxidase."
This enzyme had not been found in the natural world. The research group also used this enzyme to synthesize (S )-amine compounds ((S )-a-methylbenzylamines) through “deracemization”. These results provide a new tool for biotransformation in organic synthesis, and it is expected to be used in the production of various amine compounds.
The Exploratory Research for Advanced Technology (ERATO)
"Asano Active Enzyme Molecule Project"
Kazuyuki Yasukawa, Shogo Nakano, and Yasuhisa Asano.
“Tailoring D-amino acid oxidase from the pig kidney to R-stereoselective amine oxidase and its use in deracemization of a-methylbenzylamine” Angewandte Chemie International Edition
Dr. Yasuhisa Asano, Professor
Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University
5180 Kurokawa, Imizu,
Toyama 939-0398, Japan
Department of Research Project
Japan Science and Technology Agency (JST)