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JST Press Release

Feb. 07, 2014
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666
URL http://www.jst.go.jp/EN/index.html

Development of a new enzyme not found in the natural world.
—A tool to create chiral amine compounds by recognizing (R )-amines—

Professor Dr. Yasuhisa Asano, Research Director of Asano Active Enzyme Molecule Project, and his collaborators, Dr. Kazuyuki Yasukawa and Dr. Shogo Nakano, engineered a new enzyme "(R )-stereoselective amine oxidase."

This enzyme had not been found in the natural world. The research group also used this enzyme to synthesize (S )-amine compounds ((S )-a-methylbenzylamines) through “deracemization”. These results provide a new tool for biotransformation in organic synthesis, and it is expected to be used in the production of various amine compounds.

Researcher Information

The Exploratory Research for Advanced Technology (ERATO)
"Asano Active Enzyme Molecule Project"

Journal Information

Kazuyuki Yasukawa, Shogo Nakano, and Yasuhisa Asano.
“Tailoring D-amino acid oxidase from the pig kidney to R-stereoselective amine oxidase and its use in deracemization of a-methylbenzylamine” Angewandte Chemie International Edition
doi: 10.1002/anie.201308812


[About Research]
Dr. Yasuhisa Asano, Professor
Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University
5180 Kurokawa, Imizu,
Toyama 939-0398, Japan
TEL +81-766-88-2280
FAX +81-766-88-2422
HP: http://www.jst.go.jp/erato/asano/english/index.html

[About Program]
Tsuyoshi Nakamura
Department of Research Project
Japan Science and Technology Agency (JST)


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/