Kageyama Team　　Result

(50) 2011 Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K., and Kageyama, R. (2011) Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proc. Natl. Acad. Sci. USA 108, 8479-8484.

(49) 2011 Niwa, Y., Shimojo, H., Isomura, A., Gonzalez, A., Miyachi, H., and Kageyama, R. (2011) Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes & Dev. 25, 1115-1120.

(48) 2011Takashima, Y., Ohtsuka, T., Gonzalez, A., Miyachi, H., and Kageyama, R. (2011) Intronic delay is essential for oscillatory expression in the segmentation clock. Proc. Natl. Acad. Sci. USA 108, 3300-3305. (DOI:○10.1073/pnas.1014418108)

(47) 2011Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H., and Nakayama, K.I. (2011) Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells. J. Biol. Chem. 2011,286(15)13754-64.

(46)2010 Marcel Horning, Akihiro Isomura, Zhiheng Jia, Emilia Entcheva, and Kenichi Yoshikawa, "Utilizing the eikonal relationship in strategies for reentrant wave termination in excitable media," Physical Review E, 81(5), 056202 (2010)

(45)2010 Hiroki Nagahara and Kenichi Yoshikawa, "Large system in a small cell: A hypothetical pathway from a microscopic stochastic process towards robust genetic regulation," Chemical Physics Letters, 494(1-3), 88-94 (2010).

(44)2010 Ikeda, K., Kageyama, R., Suzuki, Y., and Kawakami, K. (2010) Six1 is indispensable for production of functional apical and basal progenitors during olfactory epithelial development. Int. J. Dev. Biol. vol.54 1453-1464.

(43)2010 Kobayashi, T. and Kageyama, R. (2010) Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes to Cells 15, 689-698. (DOI:　10.1111/j.1365-2443.2010.01413.x)

(42)2010 Karlsson, C., Brantsing, C., Kageyama, R., and Lindahl, A. (2010) HES1 and HES5 are dispensable for cartilage and endochondral bone formation. Cells Tissue Organs 192, 17-27. (DOI: 10.1159/000280416)

(41)2010Inoue, T., Coles, B., Dorval, K., Bremner, R., Bessho, Y., Kageyama, R., Hino, S., Matsuoka, M., Craft, C., McInnes, R., Temblay, F., Prusky, G., Tano, Y., and van der Kooy, D. (2010) Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells 28, 489-500. (DOI:○10.1002/stem.279)

(40)2010Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., and Hibi, M. (2010) Zinc-finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in forebrain. Development 137, 1875-1885. (DOI:○10.1242/dev.047167)

(39)2010 Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., and Kageyama, R. (2010) Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains. J. Neurosci. 30, 3489-3498

(38)2009 Nagahara, H., Ma, Y., Takenaka, Y., Kageyama, R., and Yoshikawa, K. (2009) Spatio-temporal pattern in somitogenesis: a non-Turing scenario with wave propagation. Physical Rev. E. 80, 0219106(1-7).

(37)2009Arai, M., Masada, A., Ohtsuka, T., Kageyama, R., and Ishibashi, M. (2009) The first Hes1 dimer inhibitors from natural products. Bioorganic & Medicinal Chemistry Letters 19, 5778-5781.

(36)2009 Murata, J., Ohtsuka, T., Tokunaga, A., Nishiike, S., Inohara, H., Okano, H., and Kageyama, R.(2009) Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27(Kip1). J. Neurosci. Res. 87, 3521-3534.

(35)2009 Wall, D.S., Mears, A.J., McNeill, B., Mazerolle, C., Thurig, S., Wang, Y., Kageyama, R., and Wallace, V.A. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity." J. Cell Biol. 184, 101-112.

(34)2009Gonzalez, A., and Kageyama, R. (2009) Hopf Bifurcation in the Presomitic Mesoderm during the Mouse Segmentation. J. Theor. Biol. 259, 176-189.

(33)2009Kobayashi, T., Mizuno, H., Imayoshi, I., Furusawa, C., Shirahige, K., and Kageyama, R.(2009) The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells." Genes & Dev. 23, 1870-1875.

(33) 2008 Kageyama, R., Ohtsuka, T., Shimojo, H., and Imayoshi, I. (2008) Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nature Neurosci. 11, 1247-1251.

(32) 2008 Kageyama, R. Ohtsuka, T., and Kobayashi, T. (2008) The roles of Hes genes in neural development. Dev. Growth Diff. 50, S97-S103.

(31) 2008 Yue Ma and Kenichi Yoshikawa,Self-Sustained Collective Oscillation Generated in　an Array of Non-Oscillatory Cells. （submitted to Physical Review E, first review process has been finished, under revision now.）

(30) 2008 Shimojo, H., Ohtsuka, T., and Kageyama, R. (2008) Oscillations in Notch signaling regulate maintenance of neural progenitors. Neuron 58, 52-64.

(29) 2008 Imayoshi, I., Shimogori, T., Ohtsuka, T., and Kageyama, R. (2008) Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development 135, 2531-2541.

(28) 2008 Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., and Kageyama, R. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neurosci. 11, 1153-1161.

(27) 2008 Ishii, A., Kobayashi, T., and Kageyama, R. (2008) Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. Biochem. Biophys. Res. Commun. 372, 142-146.

(26) 2008 Nakayama, K., Satoh, T., Igari, A., Kageyama, R., and Nishida, E. (2008) FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr. Biol., 18, R332-R334.

(25) 2008 Invitaion Lecture:Yoshikawa, , K.: On/Off Switchingof Higher-Order Structure in DNA, International Drug Discovery Science and Technology, Beijing, China, Oct 18 - 22, 2008.

(24) 2008 Invitaion Lecture:Oscillations in Notch signaling regulate proliferation and differentiation of neural progenitor cells. 11th Kyoto University International Symposium, Shanghai, China, Oct 9-11, 2008.

(23) 2008 Invitaion Lecture:Oscillations in Notch signaling regulate proliferation and differentiation of neural progenitor cells. 9th International Congress on Cell Biology, Seoul, Korea, Oct 7-10, 2008.

(22) 2008 Invitaion Lecture::Oscillations in Notch signaling regulate maintenance of neural progenitor cells. 18th International Congress of Eye Research, Beijing, China, Sept 24-29, 2008.

(21) 2008 Invitaion Lecture:Oscillations in Notch signaling regulate maintenance of neural progenitors. 2nd International Congress on Stem Cells and Tissue Formation. Dresden, Germany, July 6-9, 2008.

(20) 2008 Ishii, A., Kobayashi, T., and Kageyama, R. (2008) Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. Biochem. Biophys. Res. Commun. 372, 142-146.

(19) 2008 Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., and Kageyama, R. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neurosci. 11, 1153-1161.

(18) 2008 Imayoshi, I., Shimogori, T., Ohtsuka, T., and Kageyama, R. (2008) Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development 135, 2531-2541.

(17) 2008 Invitaion Lecture:Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, C.-X., Kageyama, R.: The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock. The 2nd International Workshop on Natural Computing. Nagoya, 2007.

(16) 2008 Invitaion Lecture:Kageyama, R.: Ultradian oscillators in somite segmentation and other biologica events. BMB 2007.Yokohama.2007.

(15) 2008 Invitaion Lecture:Kageyama, R., Shimojo, H. and Ohtsuka, T.: Oscillatory versus persistent Hes1 expression promotes proliferation and differentiation of neural progenitors. Neuro 2007.Yokohama.2007.

(14) 2008 Invitaion Lecture:Kageyama, R.: Ultradian oscillators in somite segmentation and other events. The 4th International Symposium on bHLH genes: Development and Diseases. Kyoto, 2007.

(13) 2008 Invitaion Lecture:Kageyama, R.: The bHLH gene network in neural development. Neurogenesis 2007. Tokyo, 2007.

(12) 2008 Invitaion Lecture:Kageyama, R.: The role of bHLH genes in neural development. The Annual Meeting of KSMBMB, Seoul, Korea, 2007

(11) 2008 Invitaion Lecture:Kageyama, R.: The role of Hes1 in brain development. The Notch Meeting, Athens, Greece, 2007.

(10) 2008 Invitaion Lecture:Kageyama, R.: The mechanism of ultradian oscillations in the somite segmentation and other events. Segmentation Meeting, Cancun, Mexico, 2007.

(9) 2008 Invitaion Lecture:Kageyama, R.: The mechanism of ultradian oscillations in the somite segmentation and other events. 72nd Cold Spring Harbor Symposium, Cold Spring Harbor, USA, 2007.

(8) 2008 Y. Takenaka, H. Nagahara, H. Kitahata and K. Yoshikawa, Large-scale on-off switching of genetic activity mediated by the folding-unfolding transition in a giant DNA molecule: An hypothesis, Physical Review E，77, 031905,　1-5 (2008).

(7) 2008 Shimojo, H., Ohtsuka, T., and Kageyama, R. (2008) Oscillations in Notch signaling regulate maintenance of neural progenitors. Neuron, 58,52-64.

(6) 2008 Nakayama, K., Satoh, T., Igari, A., Kageyama, R., and Nishida, E. (2008) FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr. Biol.,18,R332-R334.

(5) 2008 Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, C.-X., and Kageyama, R. (2007) The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock. Dev. Cell 13, 298-304.

(4) 2008 Yoshiura, S., Ohtsuka, T., Takenaka, Y., Nagahara, H., Yoshikawa, K., and Kageyama, R. (2007) Ultradian oscillations in Stat, Smad and Hes1 expression in response to serum. Proc. Natl. Acad. Sci. USA 104, 11292-11297.

(3) June 25 2007 S.Yoshiura,T.Ohtsuka,Y.Takenaka,H.Nagahara,K.Koshikawa,R.Kageyama "Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum" Proc. Natl. Acad. Sci. USA published June 25, 2007, 10.1073/pnas.0701837104 ( Cell Biology )

(2) March 29-April 1.2007"Ultradian clocks that regulate somite segmentation and other events." A joint meeting of The Genetics Society, The British Society for Developmental Biology and The British Society of Cell Biology. Eginbugh, UK.

(1) March.14.2007"The bHLH gene network in neural development" The Toshiya Yamada Memorial Lecture. Brisbane, Australia