影山チーム　　研究成果

(56) 2011年 Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K., and Kageyama, R. (2011) Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proc. Natl. Acad. Sci. USA 108, 8479-8484.

(55) 2011年 Niwa, Y., Shimojo, H., Isomura, A., Gonzalez, A., Miyachi, H., and Kageyama, R. (2011) Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes & Dev. 25, 1115-1120.

(54) 2011年Takashima, Y., Ohtsuka, T., Gonzalez, A., Miyachi, H., and Kageyama, R. (2011) Intronic delay is essential for oscillatory expression in the segmentation clock. Proc. Natl. Acad. Sci. USA 108, 3300-3305. (DOI:○10.1073/pnas.1014418108)

(53) 2011年 Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H., and Nakayama, K.I. (2011) Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells. J. Biol. Chem. 2011,286(15)13754-64.

(52) 2010年Marcel Horning, Akihiro Isomura, Zhiheng Jia, Emilia Entcheva, and Kenichi Yoshikawa, "Utilizing the eikonal relationship in strategies for reentrant wave termination in excitable media," Physical Review E, 81(5), 056202 (2010).

(51) 2010年Hiroki Nagahara and Kenichi Yoshikawa, "Large system in a small cell: A hypothetical pathway from a microscopic stochastic process towards robust genetic regulation," Chemical Physics Letters, 494(1-3), 88-94 (2010).

(50) 2010年 Ikeda, K., Kageyama, R., Suzuki, Y., and Kawakami, K. (2010) Six1 is indispensable for production of functional apical and basal progenitors during olfactory epithelial development. Int. J. Dev. Biol.54 1453-1464

(49) 2010年 Kobayashi, T. and Kageyama, R. (2010) Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes to Cells 15, 689-698. (DOI:　10.1111/j.1365-2443.2010.01413.x)

(48) 2010年 Karlsson, C., Brantsing, C., Kageyama, R., and Lindahl, A. (2010) HES1 and HES5 are dispensable for cartilage and endochondral bone formation. Cells Tissue Organs 192, 17-27. (DOI: 10.1159/000280416)

(47) 2010年 Inoue, T., Coles, B., Dorval, K., Bremner, R., Bessho, Y., Kageyama, R., Hino, S., Matsuoka, M., Craft, C., McInnes, R., Temblay, F., Prusky, G., Tano, Y., and van der Kooy, D. (2010) Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells 28, 489-500. (DOI:○10.1002/stem.279)

(46) 2010年 Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., and Hibi, M. (2010) Zinc-finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in forebrain. Development 137, 1875-1885. (DOI:○10.1242/dev.047167)

(45) 2009年Nagahara, H., Ma, Y., Takenaka, Y., Kageyama, R., and Yoshikawa, K. (2009) Spatio-temporal pattern in somitogenesis: a non-Turing scenario with wave propagation. Physical Rev. E. 80, 0219106(1-7).

(44) 2009年Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., and Kageyama, R. (2010) Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains. J. Neurosci.30,3489-3498.

(43) 2009年 Arai, M., Masada, A., Ohtsuka, T., Kageyama, R., and Ishibashi, M. (2009) The first Hes1 dimer inhibitors from natural products. Bioorganic & Medicinal Chemistry Letters 19, 5778-5781.

(42) 2009年 Murata, J., Ohtsuka, T., Tokunaga, A., Nishiike, S., Inohara, H., Okano, H., and Kageyama, R. (2009) Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27(Kip1). J. Neurosci. Res. 87, 3521-3534.

(41) 2009年 Wall, D.S., Mears, A.J., McNeill, B., Mazerolle, C., Thurig, S., Wang, Y., Kageyama, R., and Wallace, V.A. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184, 101-112

(40) 2009年 Gonzalez, A., and Kageyama, R. (2009) Hopf Bifurcation in the Presomitic Mesoderm during the Mouse Segmentation. J. Theor. Biol. 259, 176-189.

(39) 2009年 Kobayashi, T., Mizuno, H., Imayoshi, I., Furusawa, C., Shirahige, K., and Kageyama, R. (2009) "The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells." Genes & Dev. 23, 1870-1875.

(38) 2008年Kageyama, R., Ohtsuka, T., Shimojo, H., and Imayoshi, I. (2008) Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nature Neurosci. 11, 1247-1251.

(37) 2008年Kageyama, R. Ohtsuka, T., and Kobayashi, T. (2008) The roles of Hes genes in neural development. Dev. Growth Diff. 50, S97-S103.

(36) 2008年Shimojo, H., Ohtsuka, T., and Kageyama, R. (2008) Oscillations in Notch signaling regulate maintenance of neural progenitors. Neuron 58, 52-64.

(35) 2008年Nakayama, K., Satoh, T., Igari, A., Kageyama, R., and Nishida, E. (2008) FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr. Biol., 18, R332-R334.

(34) 2008年招待講演: 成体脳の神経幹細胞とニューロン新生。第４回新適塾「脳と心の神秘に迫る」、大阪、2008.

(33) 2008年招待講演:神経幹細胞の維持を制御する分子機構。第38回日本免疫学会総会・学術集会、京都、2008.

(32) 2008年招待講演: 神経幹細胞の維持を制御する分子機構。第１回Retina Research Meeting、東京、2008.

(31) 2008年招待講演:Ultradian oscillations in somite segmentation and other events. 第３回Notch研究会、三島、2008.

(30) 2008年招待講演:発生過程における短周期遺伝子発現リズム。東北大学・加齢医学研究所・ゲノムリサーチセンター・ワークショップ、仙台、2008.

(29) 2008年招待講演: Ultradian oscillatiors in somite segmentation and other events. The Uehara Memorial Foundation Symposium, Tokyo, June 30-July 2, 2008.

(28) 2008年招待講演:Yoshikawa, K.: On/Off Switchingof Higher-Order Structure in DNA, International Drug Discovery Science and Technology, Beijing, China, Oct 18 - 22, 2008.

(27) 2008年招待講演: Yoshikawa, K.: Self-running droplet: mode switching on the autonomous motion, Dynamics Days Asia Pacific 5 (DDAP5), Nara, Japan, Sep 9 ? 12, 2008.

(26) 2008年招待講演: Oscillations in Notch signaling regulate proliferation and differentiation of neural progenitor cells. 11th Kyoto University International Symposium, Shanghai, China, Oct 9-11, 2008.

(25) 2008年招待講演:Oscillations in Notch signaling regulate proliferation and differentiation of neural progenitor cells. 9th International Congress on Cell Biology, Seoul, Korea, Oct 7-10, 2008.

(24) 2008年招待講演:Oscillations in Notch signaling regulate maintenance of neural progenitor cells. 18th International Congress of Eye Research, Beijing, China, Sept 24-29, 2008.

(23) 2008年招待講演: Oscillations in Notch signaling regulate maintenance of neural progenitors. 2nd International Congress on Stem Cells and Tissue Formation. Dresden, Germany, July 6-9, 2008.

(22) 2008年Yue Ma and Kenichi Yoshikawa. Self-Sustained Collective Oscillation Generated in　an Array of Non-Oscillatory Cells, Physical Review E

(21) 2008年 Ishii, A., Kobayashi, T., and Kageyama, R. (2008) Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. Biochem. Biophys. Res. Commun. 372, 142-146.

(20) 2008年Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., and Kageyama, R. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neurosci. 11, 1153-1161.

(19) 2008年Imayoshi, I., Shimogori, T., Ohtsuka, T., and Kageyama, R. (2008) Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development 135, 2531-2541.

(18) 2008年招待講演: Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, C.-X., Kageyama, R.: The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock. The 2nd International Workshop on Natural Computing. Nagoya, 2007.

(17) 2008年招待講演: Kageyama, R.: Ultradian oscillators in somite segmentation and other biologica events. BMB 2007、Yokohama、2007.

(16) 2008年招待講演: Kageyama, R., Shimojo, H. and Ohtsuka, T.: Oscillatory versus persistent Hes1 expression promotes proliferation and differentiation of neural progenitors. Neuro 2007、Yokohama、2007.

(15) 2008年招待講演: 影山龍一郎：脳形成を制御する転写因子ネットワーク。第49回日本小児神経学会総会、大阪、2007.

(14) 2008年招待講演: Kageyama, R.: Ultradian oscillators in somite segmentation and other events. The 4th International Symposium on bHLH genes: Development and Diseases. Kyoto, 2007.

(13) 2008年招待講演: Kageyama, R.: The bHLH gene network in neural development. Neurogenesis 2007. Tokyo, 2007.

(12) 2008年招待講演: Kageyama, R.: The role of bHLH genes in neural development. The Annual Meeting of KSMBMB, Seoul, Korea, 2007

(11) 2008年招待講演: Kageyama, R.: The role of Hes1 in brain development. The Notch Meeting, Athens, Greece, 2007.

(10) 2008年招待講演: Kageyama, R.: The mechanism of ultradian oscillations in the somite segmentation and other events. Segmentation Meeting, Cancun, Mexico, 2007.

(9) 2008年招待講演: Kageyama, R.: The mechanism of ultradian oscillations in the somite segmentation and other events. 72nd Cold Spring Harbor Symposium, Cold Spring Harbor, USA, 2007.

(8) 2008年 Y. Takenaka, H. Nagahara, H. Kitahata and K. Yoshikawa, Large-scale on-off switching of genetic activity mediated by the folding-unfolding transition in a giant DNA molecule: An hypothesis, Physical Review E，77, 031905,　1-5 (2008).

(7) 2008年 Shimojo, H., Ohtsuka, T., and Kageyama, R. (2008) Oscillations in Notch signaling regulate maintenance of neural progenitors. Neuron, 58,52-64.

(6) 2008年 Nakayama, K., Satoh, T., Igari, A., Kageyama, R., and Nishida, E. (2008) FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr. Biol., 18,R332-R334.

(5) 2008年 Yoshiura, S., Ohtsuka, T., Takenaka, Y., Nagahara, H., Yoshikawa, K., and Kageyama, R. (2007) Ultradian oscillations in Stat, Smad and Hes1 expression in response to serum. Proc. Natl. Acad. Sci. USA 104, 11292-11297.

(4) 2008年Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, C.-X., and Kageyama, R. (2007) The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock. Dev. Cell 13, 298-304.

(3) 2007年6月25日京都大学で次の表題の記者発表を行った。"Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum"　Proc. Natl. Acad. Sci. USA published June 25, 2007, 10.1073/pnas.0701837104 ( Cell Biology )

(2) 2007年3月29日−4月1日イギリス、エジンバラにて、 The British Society for Developmental Biology and The British Society of Cell Biologyの A joint meeting of The Genetics Societyで、"Ultradian clocks that regulate somite segmentation and other events"の招待講演を行った。

(1) 2007年3月14日オーストラリア　ブリスベーンでのThe Toshiya Yamada Memorial Lectureで、"The bHLH gene network in neural development".の招待講演を行った。