Research Director

Toshiya Senda

High Energy Accelerator Research Organization “KEK”
Professor
website

Outline

Helicobacter Pylori, which infects gastric epithelial cells, is the strongest risk factor for stomach diseases including stomach cancer. This bacterium delivers the CagA protein into gastric epithelial cells, and the delivered CagA acts as a pathogenic scaffold/hub that promiscuously recruits host proteins to potentiate oncogenic signaling. In the present project, we aim to determine tertiary structures of CagA in complex with host proteins to understand the structural basis of the signal perturbation by CagA that triggers stomach diseases.