[Tatsutoshi Nakahata] Understanding the epigenetic modifications related to cancer development and regression


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Tatsutoshi Nakahata

Tatsutoshi Nakahata

Kyoto University
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Outline

Transient abnormal myelopoiesis (TAM) is a transient hematopoietic condition that occurs 10-20% of newborns with Down syndrome. Although TAM patients exhibit pathological findings that are similar to leukemia patients, TAM regresses spontaneously. This study will use TAM as a model for the development and regression of cancer in order to determine; 1) the alteration of epigenetic profiles during cancer regression, 2) the alteration of epigenetic profiles which leads TAM to leukemia, and 3) the underlying mechanism that provides genomic instability during fatal periods in Down syndrome patients.

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