ERATO 東原化学感覚シグナルプロジェクト Touhara Chemosensory Signal Project


Original Article

  1. [*] corresponding author, [under line] project member
  2. Hirasawa, Y.,, Shirasu, M., Okamoto, M.,* Touhara, K.*
    "Subjective unpleasantness of malodors induces a stress response"
    Psychoneuroendocrinology, DOI:10.1016/j.psyneuen.2019.03.018, in press (2019)
  3. Singh, A. K.*,, Touhara, K. Okamoto, M.*
    "Electrophysiological correlates of top-down attentional modulation in olfaction"
    Scientific Reports (9), 4953 (2019)
  4. Nagashima, A., Higaki, T., Koeduka, T., Ishigami, K., Hosokawa, S, Watanabe, H., Matsui, K, Hasezawa, S., and Touhara, K.*
    "Transcriptional regulators involved in responses to volatile organic compounds in plants"
    J. Biol. Chem., 294, 2256-2266 (2019)
  5. Horio, N., Murata, K., Yoshikawa, K., Yoshihara, Y., Touhara, K.*
    "Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice"
    Nature Communications (10),209 (2019)
  6. Osakada, T., Itakura, T., Kenmochi, R.,and Touhara, K.*
    "A sexual rejection peptide: potential use for controlling mouse overpopulation"
    Bioscience, Biotechnology,and Biochemistry, 83(4), 1-4 (2019)
  7. Osakada, T., Ishii, K. K., Mori, H., Eguchi, R., Ferrero, D. M., Yoshihara, Y., Liberles, S. D., Miyamichi, M.*, Touhara, K.*
    "Sexual rejection via a vomeronasal receptor-triggered limbic circuit"
    Nature Communications 9, 4463 (2018)
  8. Kumazaki, H.*, Okamoto, M., Yoshimura, Y., Ikeda, T., Hasegawa, C., Saito, D.N, Iwanaga, R., Tomiyama, S., An, K.M., Minabe, Y., Kikuchi, M.
    "Brief Report: Odour Awareness in Young Children with Autism Spectrum Disorders"
    J Autism Dev Disord. in press (2018)
  9. Niimura, Y.*, Matsui,A., Touhara, K.*
    "Acceleration of Olfactory Receptor Gene Loss in Primate Evolution: Possible Link to Anatomical Change in Sensory Systems and Dietary Transition"
    Mol. Biol. Evol.35(6), 1437-1450 (2018)
  10. Tsunoda, M., Miyamichi, K., Eguchi, R., Sakuma, Y., Kikusui, T., Kuwahara, M., and Touhara, K.*
    "Identification of an intra- and inter-specific tear protein signal in rodents"
    Current Biology 28, 1213-1223 (2018)
  11. Koide, T.*, Yabuki, Y., and Yoshihara, Y.*
    "Terminal nerve GnRH3 neurons mediate slow avoidance of carbon dioxide in larval zebrafish"
    Cell Reports 22(5),1115-1123 (2017)
  12. Hattori, T., Oyama, R., Horio, N., Osakada, T., Mogi, K., Nagasawa, M., Haga-Yamanaka, S., Touhara, K.*,Kikusui, T.*
    "Exocrine gland-secreting peptide 1 is a key chemosensory signal responsible for the Bruce effect in mice"
    Current Biology 27, 3197-3201 (2017)
  13. Iwata, T., Niimura, Y., Kobayashi, C., Shirakawa, D., Suzuki,H., Enomoto, T., Touhara, K., Yoshihara, Y., and Hirota, J.*
    "A long-range cis-regulatory element for class I odorant receptor genes"
    Nature Communications 8, 885 (2017)
  14. Asaba, A., Osakada, T., Touhara, K., Kato, M., Mogi, K., and Kikusui, T.*
    "Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity"
    Hormones and Behavior 94, 53-60 (2017)
  15. Ishii, K., Osakada, T., Mori, H., Miyasaka, N., Yoshihara,Y. , Miyamichi, K.*, and Touhara, K.*
    "A Labeled-Line Neural Circuit for Pheromone-Mediated Sexual Behaviors in Mice"
    Neuron, 95(1), 123-137 (2017)
  16. Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., and Yoshihara, Y.*
    "Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior"
    Nature Neuroscience 19(7) (2016)
  17. Wakisaka, N., Miyasaka, N., Koide, T., Masuda,M., Hiraki-Kajiyama, T., Yoshihara, Y.*
    "An Adenosine Receptor for Olfaction in Fish"
    J.Exp.Biol. 220, 1781-1786 (2017)
  18. Wicher, D.*, Morinaga, S., Halty-deLeon, L., Funk, N., Hansson, B., Touhara, K., and Stengl, M.
    "Identification and characterization of the bombykal receptor in the hawkmoth Manduca sexta"
    Journal of Experimental Biology 220, 1781-1786 (2017)
  19. Okamoto, M.*, Shirasu, M., Fujita, R., Hirasawa, Y., Touhara, K.
    "Child odors and parenting: A survey examination of the role of odor in child-rearing"
    PloS ONE, 11(5), e0154392 (2016)
  20. Sato-Akuhara, N., Horio, N., Kato-Namba, A., Yoshikawa, K., Niimura, Y., Ihara, S., Shirasu, M., and Touhara, K*
    "Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection"
    The Journal of Neuroscience, 36(16), 4482-4491 (2016)
  21. Kasuya, G., Fujiwara, Y., Tsukamoto, H., Morinaga, S., Ryu, S., Touhara, K., Ishitani, R., Furutani, Y., Hattori, M.*, and Nureki, O.*
    "Structural insights into the nucleotide base specificity of P2X receptors"
    Scientific report 7, 45208 (2017)
  22. Hattori, T., Osakada, T., Matsumoto, A., Matsuo, N., Haga-Yamanaka, S., Nishida, T., Mori, Y., Mogi, K., Touhara, K.*, and Kikusui, T.*
    "Self-exposure to the male pheromone ESP1 enhances male aggressiveness in mice."
    Current Biology, 26, 1229–1234 (2016)
  23. Ishii, T., Sato, K., Kakumoto, T., Miura, S., Touhara, K., Takeuchi, S., and Nakata, T.*
    "Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS"
    Nature Communications, 6, 8021 (2015)
  24. Tachibana, S., Touhara, K. and Ejima, A.*
    "Modification of Male Courtship Motivation by Olfactory Habituation via the GABAA Receptor in Drosophila melanogaster"
    PLoS ONE, DOI:10.1371/journal.pone.0135186 (2015)
  25. Takai, Y., and Touhara, K.*
    "Enantioselective recognition of menthol by mouse odorant receptors"
    Biosci. Biotechnol. Biochem., 79, 1980-1986 (2015)
  26. Hopf, T.A., Morinaga, S., Ihara, S.,Touhara, K., Marks, D.S., and Benton, R.*
    "Amino-acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors"
    Nature Communications, 6, 6077 (2015)
  27. Kato, A., Reisert, J.,Ihara, S.,Yoshikawa,K., andTouhara, K.*
    "Evaluation of the Role of G Protein-Coupled Receptor Kinase 3 in Desensitization of Mouse Odorant Receptors in a Mammalian Cell Line and in Olfactory Sensory Neurons"
    Chemical Science 39,771-780 (2014)
  28. Niimura, Y.*,Matsui, A., Touhara, K.
    "Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals"
    Genome Res,24,1485-1496 (2014)
  29. Miyasaka,N., Arganda-Carrreras, I., Wakisaka, N., Masuda,M., Sümbül, U., Seung, HS.,Yoshihara, Y.
    "Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labeling"
    Nature Communications,5,3639 (2014)
  30. Kiyokawa, Y.*, Hiroshima, S., Takeuchi, Y., and Mori, Y.
    "Social buffering reduces male rats' behavioral and corticosterone responses to a conditioned stimulus"
    Hormones and Behavior, 65, 114-118 (2014)
  31. Shirasu, M., Yoshikawa, k., Takai, Y., Nakashima, A., Takeuchi, H., Sakano, H., and Touhara, K.*
    "Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors"
    Neuron, 81, 165-178 (2014)
  32. Kiyokawa, Y.*, Kodama, Y., Takeuchi, Y., and Mori, Y.
    "Physical interaction is not necessary for the induction of housing-type social buffering of conditioned hyperthermia in male rats"
    Behavioural Brain Research, 256, 414-419 (2013)
  33. Ferrero, D.M., Moeller, L.M., Osakada, T., Horio, N., Li, Q., Roy, D.S., Cichy, A., Spehr, M., Touhara, K., and Liberles, S.D.*
    "A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system"
    Nature, 502, 368-371 (2013)
  34. Kaneko-Goto, T.#, Sato, Y.#, Katada, S.#, Kinameri, E., Yoshihara, S., Nishiyori, A., Kimura, M., Fujita, H., Touhara, K., Reed, R.R., and Yoshihara, Y.* (# equal contribution)
    "Goofy coordinates the acuity of olfactory signaling"
    The Journal of Neuroscience 33(32), 12987-12996 (2013)
  35. Nakagawa, T. and Touhara, K.*
    "Extracellular modulation of the silkmoth sex pheromone receptor activity by cyclic nucleotides"
    PLoS ONE 8(6), e63774 (2013)
  36. Yoshinaga, S.#, Sato, T.#, Hirakane, M., Esaki, K., Hamaguchi, T., Haga-Yamanaka, S., Tsunoda, M., Kimoto, H., Shimada, I., Touhara, K., and Terasawa, H.* (# equal contribution)
    "Structure of the Mouse Sex Peptide Pheromone ESP1 Reveals a Molecular Basis for Specific Binding to the Class-C G-Protein-Coupled Vomeronasal Receptor"
    The Journal of Biological Chemistry 288(22), 16064-16072 (2013)

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Review / Book chapter

  1. Ihara S, Touhara K.
    "G Protein-Coupled Receptor Kinase 3 (GRK3) in Olfaction. "
    Olfactory Receptors(Methods in Molecular Biology book series), 33-41, Humana Press, Springer, (2018)
  2. Kumazaki H, Okamoto M, kanzaki S, Okada K, Mimura M, Minabe Y, Kikuchi M
    "Approaches for Assessing Olfaction in Children with Autism Spectrum Disorder"
    in Olfactory Receptors(Methods in Molecular Biology book series), pp221-228, Humana Press(2018)
  3. Miyamichi K & Schwarz LA
    "Decoding Neural Circuit Structure and Function: Cellular Dissection Using Genetic Model Organisms "
    Connectivity and Circuit Architecture Using Transsynaptic Tracing in Vertebrates, 91-148 (2017)
  4. Touhara K, Niimura Y, Ihara S.
    "3. Vertebrate Odorant Receptors "
    Chemosensory Transduction (eds. Frank Zufall & Steven D. Munger), 49-66, Academic Press (2016)
  5. Ejima, A.
    "Pleiotropic actions of the male pheromone cis‑vaccenyl acetate in Drosophila melanogaster"
    Journal of Comparative Physiology A(2015)
  6. Touhara, K.
    "Odor and Pheromone Molecules, Receptors, and Behavioral Responses"
    The Olfactory System(Mori K. ed), Springer Tokyo, 19-38 (2014)
  7. Yoshihara, Y.
    "Zebrafish olfactory system"
    The Olfactory System(Mori K. ed), Springer Tokyo, 71-96 (2014)
  8. Abe, T. and Touhara, K.
    "Structure and function of a peptide pheromone family that stimulate the vomeronasal sensory sytems in mice"
    Biochem. Soc. Trans., 42, 873-877 (2014)
  9. Yoshihito Niimura
    "Olfactory Receptor Genes: Evolution"
    In: eLS 2014, John Wiley & Sons(2014)
  10. Yoshihito Niimura
    Identification of chemosensory receptor genes from vertebrate genomes"
    Pheromone Signaling : Methods and Protocols(Touhara K. ed), Humana Press, Springer, 95-105 (2013)
  11. Editor: Kazushige Touhara
    "Pheromone Signaling : Methods and Protocols"
    Humana Press, Springer (2013)

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  • Graduate School of Agricultural and Life Sciences, The University of Tokyo Biological Chemistry
  • Japan Science and Technology Agency